Mouse Monoclonal DDX1 Antibody

The DDX1 antibody is a crucial tool for studying the DEAD-box helicase 1 (DDX1) protein, a member of the DEAD-box RNA helicase family involved in RNA metabolism. DDX1 plays roles in transcription, RNA splicing, editing, and transport by unwinding RNA secondary structures. It is also implicated in maintaining genome stability and DNA repair. Research links DDX1 to cancer progression, particularly in neuroblastoma, breast cancer, and colorectal cancer, where its overexpression correlates with tumor aggressiveness and therapy resistance. Additionally, DDX1 interacts with viral RNAs, influencing replication of viruses like HIV-1. The antibody, typically generated in rabbits or mice using immunogenic peptide regions of DDX1. enables detection of the protein’s expression and localization via techniques like Western blot, immunohistochemistry, and immunofluorescence. Studies using DDX1 antibodies have revealed its nuclear and cytoplasmic distribution, interactions with cohesin complexes, and involvement in chromosome segregation. These findings underscore its dual roles in RNA processing and genome integrity, making the DDX1 antibody vital for exploring molecular mechanisms in cancer, virology, and genetic disorders.