Mouse Monoclonal MAPK10 Antibody

The MAPK10 antibody is a crucial tool for studying the mitogen-activated protein kinase 10 (MAPK10), also known as c-Jun N-terminal kinase 3 (JNK3). As a member of the serine/threonine kinase family, MAPK10 plays a key role in stress-activated signaling pathways, regulating cellular responses to environmental stressors, inflammation, apoptosis, and neuronal function. Unlike JNK1 and JNK2 (encoded by MAPK8 and MAPK9), JNK3 is predominantly expressed in the brain, heart, and testes, and is implicated in neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. MAPK10 antibodies are widely used to detect the expression, phosphorylation status, and localization of JNK3 in tissues or cell lines via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers employ these antibodies to investigate JNK3's role in neuronal apoptosis, synaptic plasticity, and its interaction with substrates like c-Jun. Specific MAPK10 antibodies may target distinct epitopes or post-translational modifications (e.g., phosphorylated forms at Thr221/Tyr223), enabling precise analysis of activation dynamics. Validating antibody specificity through knockout controls or peptide blocking is essential for reliable data. Its applications span neuroscience, oncology, and drug development, particularly in exploring therapeutic strategies targeting JNK signaling pathways in neurological and inflammatory diseases.