| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FNDC3B |
| Uniprot No | Q53EP0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 278-570aa |
| 氨基酸序列 | GIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPD |
| 预测分子量 | 34.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于FNDC3B重组蛋白的3篇参考文献示例(注：文献为虚构示例，仅供格式参考)：
1. **文献名称**：*FNDC3B Recombinant Protein Induces Metastasis in Hepatocellular Carcinoma via PI3K/AKT Pathway*
**作者**：Chen X, et al.
**摘要**：研究通过体外表达FNDC3B重组蛋白，发现其激活PI3K/AKT信号通路，促进肝癌细胞迁移和侵袭，提示其在肿瘤转移中的关键作用。
2. **文献名称**：*Recombinant FNDC3B Enhances Fibroblast Migration through Integrin-Mediated Signaling*
**作者**：Smith A, et al.
**摘要**：利用重组FNDC3B蛋白处理成纤维细胞，证实其通过整合素-β1调控细胞黏附和迁移，可能参与组织修复与纤维化疾病。
3. **文献名称**：*FNDC3B Recombinant Protein Suppresses Adipogenesis by Modulating Wnt/β-Catenin Activity*
**作者**：Kim S, et al.
**摘要**：研究表明，重组FNDC3B蛋白通过抑制Wnt/β-catenin通路，减少脂肪生成相关基因表达，为肥胖治疗提供潜在靶点。
如需真实文献，建议通过PubMed或Google Scholar检索关键词“FNDC3B recombinant protein”获取最新研究。
FNDC3B (Fibronectin Type III Domain-Containing Protein 3B) is a member of the fibronectin type III (FN3) domain-containing protein family, characterized by the presence of multiple FN3 repeats. These domains are known to mediate protein-protein and protein-cell interactions, playing roles in cellular adhesion, signaling, and extracellular matrix organization. FNDC3B is encoded by the FNDC3B gene and has been implicated in various physiological and pathological processes, including cell differentiation, tissue development, and cancer progression.
Recombinant FNDC3B protein is engineered in vitro using expression systems (e.g., bacterial, mammalian, or insect cells) to produce purified, functional protein for research applications. Its structure typically retains key FN3 domains required for interaction with binding partners, such as integrins or growth factor receptors. Studies suggest FNDC3B may regulate pathways like Wnt/β-catenin or TGF-β signaling, influencing cell migration, proliferation, and epithelial-mesenchymal transition (EMT). Dysregulation of FNDC3B has been linked to cancers (e.g., hepatocellular carcinoma, breast cancer) and fibrotic diseases, where it may act as a tumor suppressor or promoter depending on context.
Researchers use recombinant FNDC3B to investigate its biochemical properties, interaction networks, and role in disease mechanisms. It serves as a tool for in vitro binding assays, functional studies in cell cultures, or antibody production. Recent work also explores its potential as a biomarker or therapeutic target. However, its precise molecular functions remain understudied, necessitating further exploration of its structure-activity relationships and tissue-specific roles.
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