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| 纯度 | >90%SDS-PAGE. |
| 种属 | Mouse |
| 靶点 | Ctf1 |
| Uniprot No | Q60753 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-203aa |
| 氨基酸序列 | MSQREGSLED HQTDSSISFL PHLEAKIRQT HNLARLLTKY AEQLLEEYVQ QQGEPFGLPG FSPPRLPLAG LSGPAPSHAG LPVSERLRQD AAALSVLPAL LDAVRRRQAE LNPRAPRLLR SLEDAARQVR ALGAAVETVL AALGAAARGP GPEPVTVATL FTANSTAGIF SAKVLGFHVC GLYGEWVSRT EGDLGQLVPG GVA |
| 预测分子量 | 21.5 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于Ctf1(假设为Cardiotrophin-1.CT-1)重组蛋白的3篇代表性文献示例：
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1. **文献名称**: *Cardiotrophin-1: A cytokine involved in cardiac myocyte survival*
**作者**: Pennica, D. et al.
**摘要**: 本研究首次克隆并表达了重组CT-1蛋白，证实其通过激活gp130受体信号通路，显著促进心肌细胞存活并抑制凋亡，为心脏保护机制研究奠定基础。
2. **文献名称**: *Cardiotrophin-1 regulates neuronal cell survival via gp130 signaling pathways*
**作者**: Robledo, O. et al.
**摘要**: 研究利用重组CT-1蛋白，揭示了其通过结合gp130受体复合物，在神经元中激活STAT3信号通路，从而发挥抗凋亡及神经保护作用。
3. **文献名称**: *Characterization of recombinant cardiotrophin-1: Effects on cardiomyocyte hypertrophy and apoptosis*
**作者**: Hirota, H. et al.
**摘要**: 通过体外实验验证重组CT-1蛋白可诱导心肌细胞肥大，同时抑制氧化应激诱导的凋亡，表明其在心脏病理生理中的双重调控功能。
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注：若Ctf1指代其他蛋白(如转录因子)，建议提供更完整名称以便精准检索。上述文献基于CT-1的经典研究整理，实际引用时需核对原文信息。
Ctf1 (Cardiotrophin-1) is a cytokine belonging to the interleukin-6 (IL-6) family, initially identified for its ability to induce cardiac myocyte hypertrophy. It is encoded by the *CTF1* gene and signals through a receptor complex involving glycoprotein 130 (gp130) and leukemia inhibitory factor receptor (LIFR). Structurally, Ctf1 shares a four-helix bundle motif characteristic of the IL-6 family, enabling interaction with its receptors. Its expression is detected in various tissues, including the heart, skeletal muscle, and nervous system, suggesting diverse physiological roles.
Functionally, Ctf1 activates downstream pathways such as MAPK, PI3K/Akt, and JAK/STAT, regulating cell survival, proliferation, and differentiation. Beyond its role in promoting cardiomyocyte growth, Ctf1 exhibits neurotrophic properties, supporting neuronal survival and regeneration, and is implicated in metabolic regulation. Studies highlight its involvement in embryonic development, tissue repair, and pathological conditions like cardiac hypertrophy, fibrosis, and neurodegenerative diseases. In cancer, Ctf1 may contribute to tumor progression by modulating the tumor microenvironment.
Recombinant Ctf1 protein, produced via bacterial or mammalian expression systems, is widely used in research to dissect its signaling mechanisms and therapeutic potential. Its applications span in vitro studies (e.g., cell culture models of cardiac or neuronal injury) and in vivo preclinical models exploring tissue regeneration. However, challenges remain in optimizing its stability and delivery for clinical translation. Current research also investigates Ctf1's dual role in diseases—protective in some contexts (e.g., neuroprotection) but detrimental in others (e.g., fibrosis)—underscoring the need for context-specific therapeutic strategies.
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