首页 / 产品 / 蛋白 / 细胞因子、趋化因子与生长因子
| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | Ccl6 |
| Uniprot No | P27784 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 22-116aa |
| 氨基酸序列 | GLIQEIEKED RRYNPPIIHQ GFQDTSSDCC FSYATQIPCK RFIYYFPTSG GCIKPGIIFI SRRGTQVCAD PSDRRVQRCL STLKQGPRSG NKVIA |
| 预测分子量 | 10.7 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于Ccl6重组蛋白的3篇示例参考文献(基于公开研究主题的概括，非真实文献)：
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1. **文献名称**：*Ccl6 regulates macrophage recruitment in inflammatory responses via a novel signaling pathway*
**作者**：A. Smith et al.
**摘要**：研究利用重组Ccl6蛋白探究其在炎症模型中巨噬细胞趋化作用，发现Ccl6通过激活MAPK通路促进巨噬细胞迁移，提示其作为潜在炎症治疗靶点。
2. **文献名称**：*Expression and functional characterization of recombinant Ccl6 in a murine asthma model*
**作者**：B. Lee & C. Zhang
**摘要**：通过大肠杆菌系统表达重组Ccl6蛋白，验证其在哮喘小鼠模型中增强Th2型免疫反应的作用，表明Ccl6可能参与过敏性气道炎症的调控。
3. **文献名称**：*Ccl6 promotes tumor metastasis by enhancing myeloid-derived suppressor cell infiltration*
**作者**：K. Patel et al.
**摘要**：利用重组Ccl6蛋白处理肿瘤微环境，证实其通过招募MDSCs促进肿瘤转移，为靶向Ccl6的癌症免疫治疗提供依据。
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如需真实文献，建议在PubMed或Sci-Hub中检索关键词“Ccl6 recombinant protein”或“Ccl6 chemokine function”，并筛选近5年的研究。
Ccl6 (chemokine (C-C motif) ligand 6), also known as MRP-1 (myeloid-related protein 1), is a small secreted protein belonging to the CC chemokine family. It plays a role in immune cell recruitment, inflammation, and tissue remodeling. Initially identified in mice, Ccl6 is primarily produced by macrophages, fibroblasts, and epithelial cells under inflammatory conditions. Its human functional homolog, CCL23. shares structural similarities but differs in gene localization and regulatory mechanisms. The protein interacts with chemokine receptors such as CCR1 and CCR3. mediating leukocyte migration, particularly monocytes, neutrophils, and T cells, to sites of infection or injury.
Ccl6 is implicated in diverse physiological and pathological processes, including chronic inflammation, fibrosis, and cancer progression. Studies highlight its dual role: while promoting tissue repair in acute settings, it may exacerbate pathological remodeling in chronic diseases. In cancer, Ccl6 contributes to tumor-associated macrophage infiltration, angiogenesis, and metastasis, making it a potential therapeutic target.
Recombinant Ccl6 protein is produced using expression systems like *E. coli* or mammalian cells, ensuring proper folding and post-translational modifications. Purification involves affinity chromatography, yielding high-purity bioactive protein for experimental applications. Researchers use it to study chemotaxis, immune cell activation, receptor-ligand interactions, and signaling pathways (e.g., MAPK/ERK, PI3K/Akt) in vitro. In vivo, it helps model disease mechanisms or test blocking antibodies/inhibitors in preclinical settings. Its structure includes a conserved CC motif and a C-terminal extended domain, critical for receptor binding and oligomerization. Despite progress, Ccl6's context-dependent functions and cross-species variability warrant further exploration to clarify its therapeutic potential.
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