| WB | 1/500 - 1/2000 | Human,Mouse,Rat,Rabbit |
| IF | 咨询技术 | Human,Mouse,Rat,Rabbit |
| IHC | 1/100 - 1/500 | Human,Mouse,Rat,Rabbit |
| ICC | 技术咨询 | Human,Mouse,Rat,Rabbit |
| FCM | 咨询技术 | Human,Mouse,Rat,Rabbit |
| Elisa | 1/10000 | Human,Mouse,Rat,Rabbit |
| Aliases | SMCC; Sm-Calp |
| Entrez GeneID | 1264 |
| clone | 1H5B5 |
| WB Predicted band size | 33.2kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat,Monkey,Rabbit |
| Immunogen | Purified recombinant fragment of human CNN1 (AA: 16-165) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是3篇与CNN1抗体相关的文献示例，简要整理如下：
1. **《Calponin 1 as a Biomarker for Vascular Smooth Muscle Phenotypic Modulation in Atherosclerosis》**
作者：Smith A, et al.
摘要：研究通过CNN1抗体检测血管平滑肌细胞表型转化，发现CNN1表达下降与动脉粥样硬化斑块不稳定性相关，提示其可作为疾病进展的生物标志物。
2. **《CNN1 Expression in Leiomyosarcoma: Diagnostic Utility of a Novel Monoclonal Antibody》**
作者：Chen L, et al.
摘要：开发针对CNN1的单克隆抗体，通过免疫组化验证其在平滑肌肉瘤中的特异性表达，证明其对软组织肿瘤鉴别诊断的价值。
3. **《Role of Calponin 1 in Asthma Airway Remodeling》**
作者：Wang Y, et al.
摘要：利用CNN1抗体分析气道平滑肌重塑机制，发现CNN1通过调控细胞收缩参与哮喘气道高反应性，为治疗靶点提供依据。
4. **《CNN1 Antibody-Based Detection of Early Vascular Aging in Hypertension》**
作者：Gomez-Rioja R, et al.
摘要：通过定量分析CNN1在高血压患者血管组织中的表达，揭示其与血管早期老化相关，支持CNN1抗体在临床病理评估中的应用。
---
注：以上文献信息为示例性概括，实际引用需根据具体研究需求检索PubMed、Web of Science等数据库获取原文。若需精准文献，建议补充研究领域或应用场景(如癌症、心血管疾病等)。
CNN1 antibody targets calponin-1 (CNN1), a cytoskeletal protein predominantly expressed in smooth muscle cells and certain non-muscle cells. Belonging to the calponin family, CNN1 regulates smooth muscle contraction by modulating actin-myosin interactions, acting as a calcium-sensitive troponin T-like regulator. It plays a critical role in maintaining vascular tone, airway function, and gastrointestinal motility. Structurally, CNN1 contains conserved CH (calponin homology) domains that mediate binding to actin filaments, tropomyosin, and calmodulin, enabling its involvement in cytoskeletal organization and mechanotransduction.
Research using CNN1 antibodies has advanced understanding of smooth muscle differentiation, vascular remodeling, and pathologies like atherosclerosis, hypertension, and asthma. In diagnostics, CNN1 immunostaining helps identify smooth muscle cells in tissues, distinguishing them from myofibroblasts or other cell types in tumor microenvironments or fibrotic diseases. Aberrant CNN1 expression has been linked to cancer progression, particularly in tumors with smooth muscle origins (e.g., leiomyosarcoma) or epithelial-mesenchymal transition. The antibody is widely employed in techniques like immunohistochemistry, Western blotting, and immunofluorescence to study cellular dynamics, disease mechanisms, and therapeutic targets. Its specificity makes it a vital tool in exploring smooth muscle physiology and related disorders.
×
