Mouse Monoclonal ABCC4 Antibody

The ABCC4 antibody is a crucial tool for studying the ATP-binding cassette (ABC) transporter superfamily member ABCC4. also known as multidrug resistance-associated protein 4 (MRP4). ABCC4 is a transmembrane protein that functions as an efflux pump, transporting a variety of endogenous and exogenous substrates, including cyclic nucleotides (cAMP, cGMP), prostaglandins (PGE1. PGE2), and antiviral drugs (e.g., tenofovir). It plays a significant role in cellular detoxification, drug resistance, and signaling pathways. ABCC4 is expressed in tissues such as the liver, kidneys, prostate, and blood-brain barrier, influencing pharmacokinetics and pharmacodynamics. Its overexpression in cancers is linked to chemoresistance, particularly to nucleoside analogs and methotrexate, making it a potential therapeutic target. In platelets, ABCC4 regulates cAMP levels, modulating aggregation and thrombosis. ABCC4 antibodies enable the detection and localization of the protein via techniques like Western blotting, immunohistochemistry, and flow cytometry, aiding research into its physiological roles and pathological implications in cancer, cardiovascular diseases, and neurological disorders. Validation of these antibodies is essential, often using knockout cell lines or siRNA to ensure specificity. Understanding ABCC4's mechanisms through antibody-based studies could advance drug development and personalized treatment strategies for diseases involving dysregulated drug transport or signaling pathways.