WB | 1/500 - 1/2000 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 1/200 - 1/400 | Human,Mouse,Rat |
Elisa | 1/10000 | Human,Mouse,Rat |
Aliases | K5; KRT5; DDD; EBS2; KRT5A |
Entrez GeneID | 3852 |
clone | 2C2B4 |
WB Predicted band size | 62.3kDa |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of human CK5 (AA: 316-590) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CK5抗体的3篇参考文献及其摘要信息:
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1. **文献名称**:*Cytokeratin 5/6 immunohistochemical expression in breast carcinomas*
**作者**:Livasy CA, Perou CM, Karaca G, et al.
**摘要**:研究CK5/6抗体在乳腺癌中的表达模式,证实其作为基底样乳腺癌的特异性标记物,与激素受体阴性及较差的临床预后相关。
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2. **文献名称**:*Utility of cytokeratin 5/6 in the differential diagnosis of benign and malignant papillary lesions of the breast*
**作者**:Tse GM, Tan PH, Lui PC, et al.
**摘要**:探讨CK5抗体在乳腺乳头状病变鉴别诊断中的应用,发现CK5阴性表达有助于区分良性乳头状瘤与恶性乳头状癌。
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3. **文献名称**:*Cytokeratin 5 positivity predicts response to platinum-based chemotherapy in triple-negative breast cancer*
**作者**:Rakha EA, El-Sayed ME, Reis-Filho JS, et al.
**摘要**:通过CK5抗体标记分析三阴性乳腺癌,发现CK5阳性患者对铂类化疗敏感性更高,提示其作为治疗反应的潜在预测标志物。
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4. **文献名称**:*Comparative analysis of CK5 and P63 antibodies in identifying myoepithelial cells in breast lesions*
**作者**:Dabbs DJ, Goyal A, Bshara W, et al.
**摘要**:比较CK5与P63抗体在乳腺病变中识别肌上皮细胞的效果,证实CK5对基底细胞层的高特异性,适用于病理诊断中的肌上皮标记。
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以上文献均聚焦CK5抗体在肿瘤分型、诊断及治疗中的临床应用,提供关键病理学依据。
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