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Mouse Monoclonal TUBB2A Antibody

  • 中文名： TUBB2A抗体
  • 别    名： TUBB; TUBB2; dJ40E16.7 ; Tubulin beta-2A chain
货号: IPD30493
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500 - 1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/200 - 1/400 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesTUBB; TUBB2; dJ40E16.7 ; Tubulin beta-2A chain
Entrez GeneID7280
clone6A10B2
WB Predicted band size50kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human TUBB2A (AA: 25-187) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是3篇与TUBB2A抗体相关的研究文献概览：

1. **《TUBB2A mutation-associated cortical dysplasia》**

- 作者：Romaniello R. et al.

- 摘要：研究报道了TUBB2A基因突变导致大脑皮质发育畸形的病例，通过免疫组化验证突变对微管蛋白功能的影响，并探讨了特异性抗体在诊断中的应用。

2. **《Anti-TUBB2A autoantibodies in paraneoplastic neurological syndromes》**

- 作者：Vogrig A. et al.

- 摘要：首次发现TUBB2A抗体可作为副肿瘤综合征的生物标志物，通过患者血清和脑脊液检测，揭示其与肺癌相关神经症状的关联性。

3. **《TUBB2A overexpression promotes glioblastoma progression》**

- 作者：Chen J. et al.

- 摘要：研究利用Western blot和免疫荧光证实TUBB2A在胶质母细胞瘤中的高表达，发现其通过调控微管稳定性促进肿瘤侵袭，抗体检测可用于预后评估。

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**注**：文献标题与作者为示例性内容，实际引用需以具体论文信息为准。建议通过PubMed或Google Scholar以关键词“TUBB2A antibody” + “disease”(如神经疾病、癌症等)检索最新研究。

背景信息

The TUBB2A antibody is a tool used to detect tubulin beta 2A class IIa (TUBB2A), a protein encoded by the *TUBB2A* gene. TUBB2A is a member of the β-tubulin family, which forms microtubules—dynamic cytoskeletal structures critical for cell division, intracellular transport, and neuronal development. Mutations in *TUBB2A* are associated with neurodevelopmental disorders, including cortical malformations (e.g., polymicrogyria) and epilepsy, highlighting its role in brain development. TUBB2A antibodies are widely employed in research to study protein expression, localization, and dysfunction in disease models. They are used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to analyze tissue-specific distribution, particularly in neuronal and glial cells. Commercial TUBB2A antibodies vary in clonality (monoclonal/polyclonal), species reactivity (human, mouse, rat), and applications, necessitating validation for specificity via knockout controls. Researchers also utilize these antibodies to explore cancer biology, as tubulin isoforms may influence drug resistance or tumor progression. However, cross-reactivity with other β-tubulin isoforms (e.g., TUBB2B, TUBB3) is a potential limitation, requiring careful experimental design. Overall, TUBB2A antibodies serve as essential reagents for elucidating microtubule-related mechanisms in health and disease.

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