| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CLG4; MONA; CLG4A; TBE-1; MMP-II |
| Entrez GeneID | 4313 |
| clone | 4D1E2 |
| WB Predicted band size | 73.8kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human MMP2 (AA: 242-396) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于MMP2抗体的示例参考文献(注：以下为虚构示例，实际文献需通过学术数据库查询)：
1. **文献名称**: "MMP2 expression correlates with tumor invasion in colorectal cancer"
**作者**: Smith J, et al.
**摘要**: 本研究通过免疫组化法使用MMP2特异性抗体，发现MMP2在结直肠癌侵袭前沿高表达，提示其在肿瘤转移中的作用。
2. **文献名称**: "Role of MMP2 in myocardial remodeling post-infarction"
**作者**: Lee H, et al.
**摘要**: 通过Western blot和免疫荧光技术，利用MMP2抗体证实心肌梗死后心肌组织中MMP2活性升高，与纤维化进程相关。
3. **文献名称**: "Development of a novel monoclonal antibody for MMP2 detection in serum"
**作者**: Chen R, et al.
**摘要**: 研究团队开发了一种高特异性MMP2单克隆抗体，可灵敏检测血清中的MMP2水平，为癌症早期诊断提供新工具。
4. **文献名称**: "MMP2-mediated extracellular matrix degradation in osteoarthritis"
**作者**: Garcia M, et al.
**摘要**: 采用MMP2抗体进行组织染色，揭示了骨关节炎患者软骨组织中MMP2过度活化与基质降解的直接关联。
(提示：实际文献建议通过PubMed或Google Scholar以“MMP2 antibody”、“MMP2 immunohistochemistry”等关键词检索。)
**Background of MMP2 Antibody**
Matrix Metalloproteinase 2 (MMP2), also known as gelatinase A, is a zinc-dependent endopeptidase belonging to the MMP family, which plays a critical role in extracellular matrix (ECM) remodeling by degrading components like type IV collagen. MMP2 is involved in physiological processes such as tissue repair, angiogenesis, and embryogenesis, as well as pathological conditions including cancer metastasis, arthritis, and cardiovascular diseases. Its activity is tightly regulated at transcriptional, post-translational, and inhibitory levels (e.g., TIMPs).
MMP2 antibodies are essential tools for detecting and quantifying MMP2 expression in research and diagnostics. These antibodies target specific epitopes on MMP2. enabling applications like Western blotting, immunohistochemistry (IHC), and ELISA to study its localization, activation, or interaction with inhibitors. Monoclonal antibodies offer high specificity, while polyclonal antibodies may detect multiple isoforms or conformations. Validated MMP2 antibodies are crucial for distinguishing between latent pro-MMP2 (72 kDa) and active MMP2 (62 kDa) forms.
In research, MMP2 antibodies help elucidate its role in disease mechanisms, such as tumor invasion or inflammatory responses, and evaluate therapeutic strategies targeting MMP2 activity. Cross-reactivity with related MMPs (e.g., MMP9) should be assessed to ensure specificity. Overall, MMP2 antibodies are indispensable for advancing understanding of ECM dynamics and developing biomarkers or treatments for MMP2-associated disorders.
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