| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | RIG; REIC |
| Entrez GeneID | 27122 |
| clone | 8A5C6 |
| WB Predicted band size | 38.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat,Rabbit,Monkey |
| Immunogen | Purified recombinant fragment of human DKK3 (AA: 91-350 ) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于DKK3抗体的3篇参考文献示例(注：以下内容为示例，具体文献需根据实际研究调整)：
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1. **文献名称**: *"DKK3 Neutralizing Antibody Improves Renal Fibrosis by Blocking Wnt/β-Catenin Signaling"*
**作者**: Miao, H., Zhang, Y., & Li, X.
**摘要**: 该研究开发了一种靶向DKK3的中和抗体，并在小鼠慢性肾病模型中验证其疗效。结果显示，抗体治疗显著抑制了肾间质纤维化，机制与阻断Wnt/β-catenin信号通路的异常激活相关，提示DKK3抗体在抗纤维化治疗中的潜力。
2. **文献名称**: *"A Humanized Anti-DKK3 Antibody Enhances Chemotherapy Efficacy in Glioblastoma"*
**作者**: Foroni, C., Rossi, M., & Pellegatta, S.
**摘要**: 研究利用人源化DKK3抗体联合替莫唑胺治疗胶质母细胞瘤。实验表明，抗体通过抑制DKK3介导的肿瘤干细胞信号通路，显著增强化疗药物敏感性，并延长小鼠生存期。
3. **文献名称**: *"Development of a DKK3-Specific ELISA for Early Detection of Hepatocellular Carcinoma"*
**作者**: Wang, L., Chen, T., & Liu, S.
**摘要**: 研究基于DKK3单克隆抗体开发了高灵敏度ELISA检测方法，用于肝癌早期筛查。临床样本分析显示，血清DKK3水平在肝癌患者中显著升高，且与肿瘤分期正相关，验证了其作为新型诊断标志物的价值。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词“DKK3 antibody therapeutic”或“DKK3 biomarker”，并筛选近年研究。
DKK3 (Dickkopf-related protein 3) is a secreted glycoprotein belonging to the Dickkopf family, known for its role in modulating Wnt signaling pathways. Unlike DKK1 and DKK2. which primarily inhibit canonical Wnt/β-catenin signaling, DKK3 exhibits a more complex regulatory mechanism, interacting with diverse receptors like Kremen and LRP5/6. though its precise molecular targets remain under investigation. It is broadly expressed in adult tissues, including the kidneys, heart, and nervous system, and plays critical roles in embryonic development, tissue homeostasis, and cellular differentiation.
Dysregulation of DKK3 is implicated in multiple pathological conditions. In cancer, DKK3 often acts as a tumor suppressor, with reduced expression observed in malignancies like prostate, lung, and colorectal cancers. Conversely, it may promote fibrosis in chronic kidney disease and cardiac remodeling. DKK3 antibodies, both monoclonal and polyclonal, are vital tools for studying these processes. They enable detection of DKK3 expression via immunohistochemistry, Western blotting, or ELISA, aiding in biomarker research and therapeutic exploration. Recent studies also explore DKK3 antibodies as potential therapeutics to modulate Wnt-related pathways in diseases such as fibrosis or osteoporosis.
Despite progress, challenges persist in understanding context-specific DKK3 functions and optimizing antibody-based interventions. Ongoing research aims to clarify its dual roles in different tissues and diseases, highlighting its therapeutic and diagnostic potential.
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