| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/100 - 1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Entrez GeneID | 3037 |
| clone | 4E7 |
| WB Predicted band size | 63.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat,Monkey |
| Immunogen | Purified recombinant fragment of human HAS2 (AA: 67-170) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于HAS2抗体的3篇示例文献(注：文献为模拟示例，实际引用需核实准确性)：
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1. **标题**：*Hyaluronan Synthase 2 (HAS2) overexpression in breast cancer: Correlation with tumor progression*
**作者**：Bharadwaj AG et al.
**摘要**：研究通过免疫组化及Western blot分析，使用HAS2特异性抗体证实其在乳腺癌组织中的高表达，并发现HAS2通过调控透明质酸合成促进肿瘤侵袭和转移。
2. **标题**：*Role of HAS2 in extracellular matrix remodeling during inflammatory arthritis*
**作者**：Tolg C et al.
**摘要**：利用HAS2抗体检测小鼠关节炎模型中HAS2蛋白的动态表达，发现其介导的透明质酸合成对关节炎症和软骨破坏具有关键作用，提示HAS2作为潜在治疗靶点。
3. **标题**：*Development of a monoclonal antibody targeting human HAS2 for fibrotic disease studies*
**作者**：Sayo T et al.
**摘要**：报道一种新型HAS2单克隆抗体的开发与验证，该抗体在肺纤维化患者组织中特异性识别HAS2蛋白，并用于评估HAS2表达与疾病严重程度的相关性。
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如需实际文献，建议通过PubMed或Google Scholar检索关键词“HAS2 antibody”、“Hyaluronan Synthase 2 antibody”获取最新研究。
The hyaluronan synthase 2 (HAS2) antibody is a tool used to detect and study the HAS2 enzyme, a key player in synthesizing hyaluronan (HA), a major glycosaminoglycan in the extracellular matrix. HAS2 catalyzes the elongation of HA chains by alternately adding glucuronic acid and N-acetylglucosamine to growing polysaccharides. This enzyme is critical in physiological processes like tissue hydration, cell migration, and wound healing, as well as pathological conditions including cancer progression, fibrosis, and inflammation.
HAS2 antibodies, typically monoclonal or polyclonal, enable researchers to quantify HAS2 protein expression, localize it within cells or tissues (via techniques like immunohistochemistry or immunofluorescence), and investigate its regulatory mechanisms. Dysregulation of HAS2 is linked to excessive HA production, which promotes tumor invasiveness, stromal remodeling, and immune evasion in cancers. In fibrosis, HAS2-driven HA accumulation exacerbates tissue stiffness and fibroblast activation.
These antibodies are also used to explore therapeutic strategies targeting HA synthesis, such as inhibiting HAS2 in disease models. Studies employing HAS2 antibodies have clarified its role in developmental biology, inflammation resolution, and metabolic disorders. Their specificity and reliability make them essential for understanding HA-mediated cellular communication and microenvironment dynamics.
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