| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | HFZ5; C2orf31; MGC129692; DKFZp434E2135 |
| Entrez GeneID | 7855 |
| clone | 2D12 |
| WB Predicted band size | 64.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human FZD5 (AA:151-217) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于FZD5抗体的3篇参考文献示例(文献信息为模拟概括，实际需根据具体文献调整)：
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1. **文献名称**: *FZD5 Antibody-Based Detection Reveals Wnt Signaling Activation in Colorectal Cancer*
**作者**: Smith A, et al.
**摘要**: 本研究利用特异性FZD5抗体检测结直肠癌组织中FZD5的表达，发现其高表达与Wnt/β-catenin信号通路异常激活相关，提示FZD5可能作为癌症预后标志物。
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2. **文献名称**: *Targeting FZD5 with a Monoclonal Antibody Inhibits Tumor Angiogenesis in Triple-Negative Breast Cancer*
**作者**: Chen L, et al.
**摘要**: 通过开发靶向FZD5的单克隆抗体，研究发现其可阻断Wnt信号介导的血管生成，显著抑制三阴性乳腺癌小鼠模型的肿瘤生长，为治疗提供潜在策略。
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3. **文献名称**: *FZD5 Antibody Validation for Epithelial-Mesenchymal Transition Studies*
**作者**: Gupta R, et al.
**摘要**: 文章系统验证了多种FZD5抗体的特异性，确认其在免疫荧光和流式细胞术中的应用，并揭示FZD5在EMT过程中调控细胞迁移的机制。
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如需具体文献，建议在PubMed或Google Scholar中搜索关键词“FZD5 antibody”或“FZD5 Wnt”，筛选实验类或应用型研究。
FZD5 (Frizzled-5) is a member of the Frizzled family of G protein-coupled receptors that primarily act as receptors for Wnt signaling molecules. These receptors play critical roles in embryonic development, tissue homeostasis, and stem cell regulation by mediating both canonical (β-catenin-dependent) and non-canonical Wnt pathways. FZD5 specifically binds Wnt ligands like Wnt5a and Wnt11. influencing processes such as cell polarity, proliferation, and differentiation. Dysregulation of FZD5 is implicated in various cancers, including colorectal, breast, and gastric cancers, where it often promotes tumor progression, metastasis, and drug resistance.
FZD5 antibodies are immunological tools designed to detect or inhibit FZD5 protein expression. They are widely used in research to study Wnt signaling mechanisms, assess FZD5 expression patterns in normal vs. diseased tissues (e.g., via Western blot, immunohistochemistry, or flow cytometry), and explore therapeutic targeting. Monoclonal FZD5 antibodies, in particular, are valued for their specificity in blocking receptor-ligand interactions, making them potential candidates for anticancer therapies. Challenges in antibody development include minimizing cross-reactivity with other Frizzled family members due to structural similarities. Recent studies also highlight FZD5's role in metabolic diseases and regenerative medicine, broadening its biomedical relevance.
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