Mouse Monoclonal PAX5 Antibody

The PAX5 antibody targets the PAX5 protein, a transcription factor encoded by the *PAX5* gene, which belongs to the PAX (paired box) family of developmental regulators. PAX5 is critical for B-cell lineage commitment, differentiation, and maintenance. During B-lymphocyte development, it activates genes essential for B-cell receptor signaling (e.g., *CD19*, *BLNK*) and represses genes associated with alternative cell lineages, ensuring B-cell identity. Aberrant PAX5 expression or mutations are linked to B-cell malignancies, including B-cell acute lymphoblastic leukemia (B-ALL) and diffuse large B-cell lymphoma (DLBCL). PAX5 antibodies are widely used in research and diagnostics to identify B-cell neoplasms via immunohistochemistry (IHC) or flow cytometry, aiding in distinguishing B-cell-derived tumors from T-cell or myeloid malignancies. Additionally, PAX5 is a tumor suppressor; its loss or dysfunction may drive oncogenesis by disrupting normal B-cell maturation. In clinical settings, PAX5 expression patterns help subclassify lymphomas and guide therapeutic decisions. Studies also explore its role in autoimmune diseases and immune deficiencies, as PAX5 mutations impair antibody production. Overall, PAX5 antibodies serve as vital tools for understanding B-cell biology, disease mechanisms, and improving diagnostic precision in hematopathology.