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Mouse Monoclonal COTL1 Antibody

  • 中文名: COTL1抗体
  • 别    名: CLP
货号: IPD30322
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/200 - 1/400 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesCLP
Entrez GeneID23406
clone5C8E3
WB Predicted band size16kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human COTL1 expressed in E. Coli.  
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于COTL1抗体的3篇参考文献概览(文献名为示例性标题,作者为虚拟名称,内容基于典型研究方向整理):

1. **标题**:*COTL1 regulates neutrophil migration via interaction with actin cytoskeleton*

**作者**:Smith A, et al.

**摘要**:研究利用COTL1抗体进行免疫荧光和Western blot实验,发现COTL1通过调控肌动蛋白重塑促进中性粒细胞趋化,为炎症反应机制提供新见解。

2. **标题**:*Coactosin-like protein 1 (COTL1) as a prognostic marker in colorectal cancer*

**作者**:Zhang L, et al.

**摘要**:通过COTL1抗体进行免疫组化分析,证明COTL1在结直肠癌中高表达,且与患者生存率负相关,提示其作为潜在治疗靶点。

3. **标题**:*COTL1 modulates macrophage polarization through NF-κB signaling*

**作者**:Wang Y, et al.

**摘要**:使用COTL1抗体敲低实验,发现COTL1通过NF-κB通路调控巨噬细胞向M1表型极化,影响肿瘤微环境中的免疫应答。

(注:以上为模拟文献,实际文献需通过PubMed、Google Scholar等平台以“COTL1 antibody”或“COTL1 function”为关键词检索获取。)

背景信息

The COTL1 (Coactosin-like protein 1) antibody is a tool used to detect and study the COTL1 protein, a member of the actin-binding protein family. COTL1 is involved in regulating cytoskeletal dynamics by interacting with F-actin and cofilin, playing roles in cell migration, immune responses, and inflammatory processes. It is highly expressed in immune cells, such as macrophages and neutrophils, and has been implicated in diseases like cancer, autoimmune disorders, and chronic inflammation. Researchers use COTL1 antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze its expression patterns, subcellular localization, and interactions in both physiological and pathological contexts. Recent studies highlight its potential as a biomarker or therapeutic target, particularly in tumor metastasis and inflammatory pathways. The antibody's specificity and reliability are critical for elucidating COTL1's molecular mechanisms and clinical relevance.

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