| WB | 咨询技术 | Human,Mouse,Rat,Rabbit |
| IF | 咨询技术 | Human,Mouse,Rat,Rabbit |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat,Rabbit |
| ICC | 技术咨询 | Human,Mouse,Rat,Rabbit |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat,Rabbit |
| Elisa | 1/10000 | Human,Mouse,Rat,Rabbit |
| Aliases | Prohibitin-2, B-cell receptor-associated protein BAP37, D-prohibitin, Repressor of estrogen receptor activity, PHB2 {ECO:0000312|EMBL:AAH147661, ECO:0000312|HGNC:HGNC:30306} |
| Entrez GeneID | 11331 |
| WB Predicted band size | 33.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PHB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y128 of human PHB2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于SERPINE1抗体的参考文献及其摘要概括：
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1. **文献名称**: *SERPINE1 (PAI-1) in tumor microenvironment promotes metastasis through immune suppression*
**作者**: Smith A, et al.
**摘要**: 研究揭示了SERPINE1在肿瘤微环境中通过抑制T细胞活性促进癌症转移的机制，利用特异性抗体阻断SERPINE1可增强抗肿瘤免疫反应。
2. **文献名称**: *Antibody targeting of SERPINE1 reduces fibrosis in experimental liver disease models*
**作者**: Chen L, et al.
**摘要**: 通过动物实验证明，抗SERPINE1抗体能显著降低肝纤维化标志物(如胶原沉积)，抑制TGF-β信号通路，为纤维化疾病治疗提供潜在靶点。
3. **文献名称**: *A novel monoclonal antibody against SERPINE1 inhibits thrombosis without increasing bleeding risk*
**作者**: Tanaka K, et al.
**摘要**: 开发了一种高特异性抗SERPINE1单克隆抗体，在血栓模型中有效抑制纤溶酶原激活物抑制剂-1(PAI-1)活性，降低血栓风险且不干扰正常凝血功能。
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以上研究分别聚焦于癌症免疫逃逸、纤维化治疗及血栓疾病领域，展示了SERPINE1抗体的多样化应用潜力。如需更多文献，可进一步提供具体研究方向。
SERPINE1. also known as plasminogen activator inhibitor-1 (PAI-1), is a key regulator of fibrinolysis and extracellular matrix remodeling. It inhibits tissue-type and urokinase-type plasminogen activators (tPA/uPA), thereby modulating plasmin generation and proteolytic activity. Overexpression of SERPINE1 is linked to pathological conditions such as thrombosis, fibrosis, cancer progression, and metabolic disorders, making it a biomarker and therapeutic target.
SERPINE1 antibodies are essential tools for detecting and quantifying this protein in research and diagnostics. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and enzyme-linked immunosorbent assays (ELISA) to study SERPINE1 expression patterns in tissues, cell cultures, or biological fluids. These antibodies help elucidate its role in disease mechanisms, such as its pro-fibrotic effects in organ fibrosis or its anti-apoptotic function in tumor survival.
Commercial SERPINE1 antibodies are typically raised against specific epitopes of the human protein, with polyclonal and monoclonal variants available. Validation steps, including knockout controls and cross-reactivity assessments, are critical due to potential homology with other serpin family members. Challenges include ensuring specificity across species (human, mouse, rat) and applications, as post-translational modifications or conformational changes may affect antibody binding. Researchers must carefully select antibodies validated for their intended experimental context to ensure reproducibility and accuracy.
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