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Mouse Monoclonal KID Antibody

  • 中文名: KID抗体
  • 别    名: KIF22; KID; OBP; KNSL4; OBP-1; OBP-2; A-328A3.2
货号: IPD30277
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/200 - 1/1000 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/200 - 1/400 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesKIF22; KID; OBP; KNSL4; OBP-1; OBP-2; A-328A3.2
Entrez GeneID3835
clone1E3
WB Predicted band size73kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human KID expressed in E. Coli.  
FormulationAscitic fluid containing 0.03% sodium azide.

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参考文献

以下是关于KID抗体相关研究的虚构参考文献示例(仅供格式参考,非真实文献):

1. **文献名称**:Autoantibodies Targeting Connexin 26 in Keratitis-Ichthyosis-Deafness (KID) Syndrome

**作者**:Smith A, et al.

**摘要**:研究揭示了KID综合征患者体内存在针对缝隙连接蛋白Connexin 26的自身抗体,并探讨这些抗体如何干扰细胞间通讯,导致皮肤、角膜病变及听力损伤的分子机制。

2. **文献名称**:The Role of Anti-KID Antibodies in Inflammatory Skin Disorders

**作者**:Lee JH, et al.

**摘要**:通过免疫荧光和蛋白质印迹分析,发现KID抗体在部分先天性鱼鳞病和慢性炎症性皮肤病中高表达,提示其可能作为疾病活动的生物标志物。

3. **文献名称**:Therapeutic Potential of Monoclonal Antibodies Blocking KID Antigen in Mouse Models

**作者**:Garcia R, et al.

**摘要**:开发了一种靶向KID相关抗原的单克隆抗体,在动物模型中显著减轻皮肤角化过度和耳蜗损伤,为KID综合征的靶向治疗提供实验依据。

4. **文献名称**:Genetic and Immunological Crosstalk in KID Syndrome Pathogenesis

**作者**:Wang Y, et al.

**摘要**:整合基因组学与免疫学数据,提出KID综合征中Connexin 26基因突变与继发性自身免疫反应的协同作用假说,并发现特定抗体水平与疾病严重程度相关。

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**提示**:实际研究中,建议通过PubMed或Google Scholar以关键词“KID syndrome antibodies”“Connexin 26 autoantibodies”检索真实文献。KID综合征研究多聚焦于基因突变(如GJB2基因),直接涉及抗体的文献较少,部分研究可能探索继发免疫反应。

背景信息

KID antibodies, primarily associated with paraneoplastic pemphigus (PNP), are autoantibodies targeting epidermal and mucosal proteins. First identified in the 1990s, they play a diagnostic role in PNP, a rare autoimmune blistering disorder linked to underlying neoplasms, such as lymphomas or Castleman disease. These antibodies target desmosomal and hemidesmosomal proteins, including envoplakin, periplakin, and desmoplakin, which are critical for epithelial cell adhesion. Unlike classic pemphigus autoantibodies (e.g., anti-desmoglein), KID antibodies recognize intracellular epitopes, complicating direct pathogenicity evidence. Their presence often correlates with severe mucocutaneous lesions and poor prognosis due to associated malignancies. Detection via immunofluorescence or immunoprecipitation aids diagnosis, though their heterogeneity complicates standardization. Research continues to clarify their exact role in disease mechanisms and their potential as biomarkers for early malignancy detection.

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