| WB | 1/500 - 1/2000 | Human,Mouse,Monkey,Rat |
| IF | 咨询技术 | Human,Mouse,Monkey,Rat |
| IHC | 咨询技术 | Human,Mouse,Monkey,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Monkey,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Monkey,Rat |
| Elisa | 1/10000 | Human,Mouse,Monkey,Rat |
| Aliases | CCTB; 99D8.1; PRO1633; CCT-beta; MGC142074; MGC142076; TCP-1-beta |
| Entrez GeneID | 10576 |
| clone | 5B5C4 |
| WB Predicted band size | 54kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Monkey,Rat |
| Immunogen | Purified recombinant fragment of human CCT2 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CCT2抗体的3篇示例参考文献(内容为模拟概括，仅供参考)：
1. **文献名称**：*CCT2 regulates cancer cell motility through RhoA signaling*
**作者**：Li X, et al.
**摘要**：该研究利用CCT2抗体探究了CCT2在肿瘤细胞迁移中的作用，发现其通过调控RhoA蛋白活性影响细胞骨架重组，提示CCT2可能成为癌症治疗的潜在靶点。
2. **文献名称**：*Characterization of a monoclonal antibody specific for human CCT2 subunit*
**作者**：Yamazaki K, et al.
**摘要**：研究报道了一种高特异性CCT2单克隆抗体的开发与验证，证实其在免疫印迹(Western blot)和免疫荧光中的有效性，为CCT2功能研究提供了可靠工具。
3. **文献名称**：*CCT2 expression correlates with poor prognosis in hepatocellular carcinoma*
**作者**：Wang Y, et al.
**摘要**：通过免疫组化(IHC)结合CCT2抗体，研究发现CCT2在肝癌组织中高表达且与患者生存率负相关，提示其可作为肝癌预后的生物标志物。
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**注意**：以上文献信息为示例性质，实际引用时需通过PubMed或学术数据库核实真实文献。
The CCT2 antibody targets the Chaperonin Containing TCP-1 subunit 2 (CCT2), a component of the eukaryotic chaperonin complex CCT (also known as TRiC). This complex, composed of eight distinct subunits (CCT1-8), facilitates ATP-dependent folding of nascent polypeptides, particularly cytoskeletal proteins like actin and tubulin. CCT2 plays a critical role in maintaining proteostasis by assisting in the structural maturation of these proteins, which are essential for cell division, cytoskeletal organization, and intracellular transport. Dysregulation of CCT2 has been implicated in cancer progression, neurodegenerative diseases, and cellular stress responses due to its involvement in protein aggregation prevention and stress signaling pathways.
Antibodies against CCT2 are widely used in research to study its expression, localization, and interactions. For example, they help detect CCT2 levels via Western blotting, immunofluorescence, or immunohistochemistry, revealing its upregulation in certain cancers or altered distribution in disease models. CCT2 antibodies also aid in co-immunoprecipitation assays to identify binding partners or assess post-translational modifications. Both monoclonal and polyclonal variants exist, with specificity validated through knockdown/knockout controls. Recent studies explore CCT2's role beyond protein folding, including its potential as a therapeutic target in oncology and its involvement in cellular senescence. However, cross-reactivity with other CCT subunits remains a technical consideration during experimental design.
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