Mouse Monoclonal FGG Antibody

Fibrinogen gamma chain (FGG) antibodies are immunological tools targeting the gamma subunit of fibrinogen, a critical plasma glycoprotein involved in hemostasis and thrombosis. Fibrinogen, composed of two sets of three polypeptide chains (Aα, Bβ, and γ), is enzymatically converted to fibrin during clot formation. The gamma chain plays a key role in fibrin polymerization, platelet aggregation, and cross-linking mediated by factor XIIIa. FGG antibodies are widely utilized in research and diagnostics to study fibrinogen structure, function, and disorders. They help detect genetic variants (e.g., FGG mutations linked to dysfibrinogenemia or hypofibrinogenemia) and assess fibrinogen levels in conditions like liver disease, disseminated intravascular coagulation (DIC), or inflammatory states. In cancer research, FGG antibodies investigate tumor-associated fibrinogen expression, as aberrant fibrin deposition influences metastasis and angiogenesis. Commercially available FGG antibodies include monoclonal and polyclonal types, validated for techniques like Western blot, ELISA, and immunohistochemistry. Recent studies also explore their potential in targeting fibrin-rich tumor microenvironments for therapeutic purposes. However, cross-reactivity with fibrinogen degradation products (e.g., D-dimers) requires careful validation in clinical assays.