| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CLG; CLGN |
| Entrez GeneID | 4312 |
| clone | 6A5 |
| WB Predicted band size | 54kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human MMP1 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MMP1抗体的3篇示例参考文献(内容为示例，建议通过学术数据库验证后使用)：
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1. **文献名称**: *MMP1 as a Biomarker for Early-Stage Cancer Detection: A Monoclonal Antibody Approach*
**作者**: Smith A, et al.
**摘要**: 本研究开发了一种针对MMP1的高特异性单克隆抗体，用于检测血清中的MMP1水平。通过ELISA和免疫印迹验证，该抗体在早期结直肠癌患者样本中显示出高灵敏度，提示其作为非侵入性癌症诊断工具的潜力。
2. **文献名称**: *Targeting MMP1 in Tumor Microenvironment: Therapeutic Implications of a Neutralizing Antibody*
**作者**: Zhang L, et al.
**摘要**: 研究利用中和性MMP1抗体抑制肿瘤微环境中的胶原降解活性，发现其能显著降低小鼠模型中乳腺癌细胞的侵袭和转移。抗体治疗组肿瘤体积缩小35%，且未观察到明显毒性。
3. **文献名称**: *Comparative Analysis of MMP1 Antibody Specificity in Human Fibrotic Tissues*
**作者**: Tanaka K, et al.
**摘要**: 通过免疫组化比较三种市售MMP1抗体在肺纤维化组织中的表现，发现克隆号AB-234的抗体特异性最佳，能清晰定位MMP1在成纤维细胞中的表达，为病理诊断提供了可靠工具。
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**检索建议**：
- 在PubMed或Google Scholar中搜索关键词：**MMP1 antibody cancer/therapy/diagnosis**
- 限定近年文献(如2020年后)可获取最新应用进展。
- 关注高影响力期刊：*Nature Cancer, Journal of Pathology, Clinical Cancer Research*等。
**Background of MMP1 Antibody**
Matrix Metalloproteinase 1 (MMP1), also known as collagenase-1. is a member of the MMP family involved in extracellular matrix (ECM) remodeling. It specifically degrades fibrillar collagens (types I, II, III) and plays critical roles in physiological processes like tissue repair, embryonic development, and pathological conditions such as cancer metastasis, arthritis, and cardiovascular diseases. MMP1 expression is tightly regulated at transcriptional, translational, and post-translational levels, with its activity influenced by cytokines, growth factors, and inhibitors (TIMPs).
MMP1 antibodies are immunological tools designed to detect and quantify MMP1 in biological samples. These antibodies are widely utilized in techniques like immunohistochemistry (IHC), Western blotting, ELISA, and immunofluorescence to study MMP1 localization, expression levels, and dynamics in diseases. In cancer research, elevated MMP1 correlates with tumor invasiveness and poor prognosis, making it a potential therapeutic target or biomarker. Antibodies targeting specific MMP1 epitopes (e.g., catalytic domains) help elucidate its functional roles in disease mechanisms.
Developed as monoclonal or polyclonal forms, MMP1 antibodies vary in specificity and cross-reactivity, requiring validation for experimental models. Their applications extend to drug development, where they assess MMP1 inhibition efficacy. However, challenges include distinguishing between pro-enzyme and active forms, and avoiding cross-reactivity with homologous MMPs. Overall, MMP1 antibodies remain indispensable for advancing research in ECM biology and translational medicine.
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