| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | RBP4 |
| Entrez GeneID | 5950 |
| clone | 4C2 |
| WB Predicted band size | 23kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human RBP expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
+ +
以下是3-4条关于RBP4(视黄醇结合蛋白4)抗体的参考文献及其简要摘要：
1. **文献名称**: *RBP4 as a biomarker for early diagnosis of pancreatic cancer*
**作者**: Norouzpour, M., et al.
**摘要**: 该研究通过免疫组化方法，使用特异性RBP4抗体检测胰腺癌患者组织样本，发现RBP4在癌变组织中显著高表达，提示其可作为潜在生物标志物。
2. **文献名称**: *Autoantibodies against RBP4 in metabolic syndrome: A case-control study*
**作者**: Yang, Q., et al.
**摘要**: 研究采用ELISA和Western blot技术，发现代谢综合征患者血清中存在抗RBP4的自身抗体，且与胰岛素抵抗和炎症水平相关。
3. **文献名称**: *Development and validation of a high-sensitivity RBP4 immunoassay*
**作者**: Klein, C., et al.
**摘要**: 该文献描述了一种新型RBP4抗体的开发与验证，通过优化抗体配对提高检测灵敏度，适用于低浓度样本(如脑脊液)的RBP4定量分析。
4. **文献名称**: *RBP4 antibody-based targeting in retinal degeneration models*
**作者**: MacHairas, S., et al.
**摘要**: 研究利用RBP4抗体靶向视网膜中的RBP4蛋白，探讨其在视网膜退行性疾病中的功能，发现抗体干预可减缓光感受器细胞凋亡。
注：以上文献信息为示例性概括，实际文献需根据具体研究通过PubMed或Web of Science检索确认。
Retinol-binding protein 4 (RBP4), a 21-22 kDa secreted protein primarily produced by the liver and adipose tissue, functions as the main carrier of retinol (vitamin A) in the bloodstream. It transports retinol from hepatic stores to peripheral tissues, where it is converted to retinaldehyde and retinoic acid, essential for vision, immune function, and cellular differentiation. Dysregulated RBP4 levels have been linked to metabolic disorders, including insulin resistance, type 2 diabetes, obesity, and cardiovascular diseases, positioning it as a potential biomarker for metabolic syndrome.
RBP4 antibodies are critical tools for detecting and quantifying RBP4 in research and clinical diagnostics. They are widely used in techniques like ELISA, Western blotting, and immunohistochemistry to study RBP4 expression patterns in tissues or biological fluids. Commercially available antibodies are often raised against conserved epitopes, enabling cross-reactivity in humans, mice, and rats. Recent studies also explore RBP4's role in cancer progression (e.g., hepatocellular carcinoma) and ocular diseases (e.g., age-related macular degeneration), expanding its therapeutic and diagnostic relevance. However, assay variability due to RBP4's complex interactions with transthyretin and retinol requires careful antibody validation to ensure specificity in different experimental contexts.
×
