Mouse Monoclonal MAP2K6 Antibody

The MAP2K6 antibody is a crucial tool for studying the mitogen-activated protein kinase kinase 6 (MAP2K6), also known as MEK6 or MKK6. a serine/threonine kinase within the MAPK signaling pathway. MAP2K6 functions as a key upstream activator of p38 MAPK, regulating cellular responses to stress, cytokines, and growth factors. It plays roles in inflammation, apoptosis, autophagy, and cell differentiation. Researchers use MAP2K6 antibodies to detect and quantify the expression, localization, and activation status of MAP2K6 in various biological samples, including tissues, cell lysates, and primary cells. These antibodies are widely applied in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and immunoprecipitation (IP). MAP2K6 dysregulation has been implicated in cancer, neurodegenerative diseases, and autoimmune disorders, making its antibody valuable for both basic research and clinical investigations. Most MAP2K6 antibodies target specific epitopes, such as phosphorylated residues (e.g., Thr-207/Ser-211) or conserved regions, to distinguish active versus inactive forms. Validation typically includes knockout cell lines or siRNA knockdown to confirm specificity. Host species (rabbit, mouse) and clonality (monoclonal/polyoclonal) vary, allowing flexibility for experimental design.