| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | COX4; COXIV; COX4-1; MGC72016; COX4I1 |
| Entrez GeneID | 1327 |
| clone | 6B3 |
| WB Predicted band size | 19kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Loading Control Antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat,Monkey |
| Immunogen | Purified recombinant fragment of human COX4I1 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于COX4I1抗体的3篇示例参考文献(注：内容为模拟概括，仅供参考)：
1. **标题**：*COX4I1 modulates mitochondrial respiration and oxidative stress in hypoxic cancer cells*
**作者**：Kim H, et al.
**摘要**：研究利用COX4I1抗体分析缺氧条件下肿瘤细胞的线粒体功能，发现COX4I1通过调节复合体IV活性影响ROS生成，提示其在癌症适应性中的作用。
2. **标题**：*Antibody-based detection of COX4I1 as a biomarker for mitochondrial disorders*
**作者**：Garcia J, et al.
**摘要**：开发特异性COX4I1抗体用于ELISA和免疫组化，验证其在线粒体疾病患者血清和组织中的表达异常，为诊断提供潜在工具。
3. **标题**：*COX4I1 deficiency impairs cardiac energy metabolism via disrupting mitochondrial supercomplex assembly*
**作者**：Chen L, et al.
**摘要**：通过COX4I1抗体敲除实验，发现其缺失导致心肌细胞线粒体超复合体结构异常，引发ATP合成障碍和心力衰竭。
如需真实文献，建议通过PubMed或Google Scholar检索关键词“COX4I1 antibody”或“COX4I1 function”。
The COX4I1 antibody targets cytochrome c oxidase subunit 4 isoform 1 (COX4I1), a critical component of mitochondrial complex IV in the electron transport chain. COX4I1 is a nuclear-encoded subunit that stabilizes the complex and regulates its activity, playing a central role in cellular energy production via oxidative phosphorylation. This isoform is ubiquitously expressed, though its expression varies across tissues, with higher levels observed in metabolically active organs like the heart and liver.
COX4I1 antibodies are widely used in research to investigate mitochondrial function, metabolic disorders, and diseases linked to oxidative stress, such as cancer, neurodegenerative conditions, and cardiovascular pathologies. They enable the detection and quantification of COX4I1 protein levels through techniques like Western blotting, immunohistochemistry, and immunofluorescence, helping to assess mitochondrial health and complex IV assembly. Studies have explored COX4I1's role in hypoxia adaptation, as its expression may shift under low-oxygen conditions, influencing cellular energy metabolism. Additionally, COX4I1 dysregulation has been implicated in tumor progression, with some cancers showing altered expression correlating with prognosis.
These antibodies are typically validated for specificity across species (e.g., human, mouse, rat) and are essential tools for understanding mitochondrial biology and its implications in disease mechanisms.
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