| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | RAB10 |
| Entrez GeneID | 10890 |
| clone | 4E2 |
| WB Predicted band size | 22.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Purified recombinant fragment of human Rab10 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于Rab10抗体的示例参考文献(注：以下内容为模拟示例，实际文献请通过学术数据库检索)：
---
1. **标题**：Rab10 regulates insulin-stimulated GLUT4 trafficking in adipocytes
**作者**：Chen Y, et al.
**摘要**：研究使用Rab10特异性抗体揭示其在脂肪细胞中调控胰岛素介导的GLUT4囊泡运输的作用，表明Rab10缺失导致葡萄糖摄取障碍。
2. **标题**：Rab10 antibody reveals polarized localization in neuronal axons
**作者**：Saito N, et al.
**摘要**：通过Rab10抗体的免疫荧光染色，发现Rab10在神经元轴突中极性分布，参与轴突生长和突触囊泡的定向运输。
3. **标题**：Rab10 knockout validation using CRISPR and antibody-based detection
**作者**：Wang L, et al.
**摘要**：结合CRISPR基因编辑与Rab10抗体Western blot分析，验证Rab10敲除细胞系，并证实其在细胞外泌体分泌中的关键功能。
4. **标题**：Dysregulated Rab10 expression in Alzheimer's disease models
**作者**：Gomez T, et al.
**摘要**：利用Rab10抗体检测阿尔茨海默病模型小鼠脑组织，发现Rab10表达异常与β-淀粉样蛋白转运紊乱相关。
---
建议通过PubMed、Google Scholar等平台以“Rab10 antibody”或“Rab10 function”为关键词搜索最新文献。
Rab10 antibody is a key tool for studying the Rab10 protein, a member of the Rab GTPase family involved in regulating intracellular vesicle trafficking and membrane dynamics. Rab10 plays critical roles in maintaining cellular homeostasis, including mediating exocytosis, endosomal recycling, and autophagy. It is particularly significant in neuronal cells, where it contributes to axon outgrowth, synaptic vesicle transport, and maintaining neuronal polarity. Dysregulation of Rab10 has been linked to neurological disorders (e.g., Alzheimer’s disease, Parkinson’s disease), metabolic conditions (e.g., diabetes), and cancer, highlighting its broad physiological relevance.
Rab10 antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect expression levels, subcellular localization, and protein interactions. Researchers rely on these antibodies to explore Rab10’s role in cellular processes, such as its interaction with effector proteins or its activation state via GTP/GDP binding. Specific antibody clones (e.g., monoclonal vs. polyclonal) and host species (e.g., rabbit, mouse) offer flexibility for experimental designs. Validation methods, including knockout cell lines or siRNA knockdown, ensure antibody specificity. Given Rab10’s emerging importance in membrane trafficking pathways and disease mechanisms, its antibodies remain essential for advancing research in cell biology and therapeutic development.
×
