| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CCK4; PTK7 |
| Entrez GeneID | 5754 |
| clone | 4F9 |
| WB Predicted band size | 118kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PTK7 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于PTK7抗体的代表性文献摘要概览：
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1. **"PTK7 monoclonal antibody inhibits Wnt signaling and suppresses tumor growth in colorectal cancer"**
*Author: Zhang Y et al.*
**摘要**：研究开发了一种靶向PTK7的单克隆抗体，通过阻断Wnt/β-catenin信号通路抑制结直肠癌细胞的增殖和迁移，并在小鼠模型中显著降低肿瘤体积。
2. **"Anti-PTK7 Antibody-Drug Conjugates for Targeted Therapy of Acute Myeloid Leukemia"**
*Author: Golubovskaya V et al.*
**摘要**：报道了一种PTK7抗体药物偶联物(ADC)，通过特异性结合白血病细胞表面的PTK7.递送细胞毒性药物，在体外和体内实验中显示高效抗白血病活性且毒性可控。
3. **"PTK7 as a Biomarker for Ovarian Cancer: Diagnostic Potential of a Novel Anti-PTK7 Antibody"**
*Author: Li H et al.*
**摘要**：验证了一种新型PTK7抗体在卵巢癌组织中的高特异性表达，证明其可作为诊断标志物，并揭示PTK7过表达与患者预后不良相关。
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这些研究展示了PTK7抗体在癌症靶向治疗、信号通路调控及诊断中的应用潜力。如需具体文献来源，可进一步通过PubMed或Google Scholar检索标题及作者获取全文。
PTK7 (Protein Tyrosine Kinase 7), also known as CCK4. is a transmembrane receptor belonging to the receptor tyrosine kinase (RTK) family, though it lacks intrinsic kinase activity due to a modified catalytic domain. Initially identified for its role in embryonic development and cell motility, PTK7 regulates planar cell polarity and non-canonical Wnt signaling pathways. It features an extracellular domain with seven immunoglobulin-like repeats, a transmembrane region, and a cytoplasmic pseudokinase domain. Dysregulation of PTK7 is implicated in cancer progression, including colorectal, lung, and acute myeloid leukemia, where it often exhibits overexpression linked to tumor invasion, metastasis, and poor prognosis.
PTK7 antibodies are essential tools for studying its biological functions and pathological roles. They enable detection of PTK7 expression in tissues or cells via techniques like immunohistochemistry, flow cytometry, and Western blot. Therapeutic PTK7-targeting antibodies are under exploration, particularly in antibody-drug conjugates (ADCs) and CAR-T cell therapies, leveraging its cancer-specific expression for precision targeting. Research also highlights PTK7's potential as a diagnostic or prognostic biomarker. However, its dual roles in tumor suppression and promotion, depending on context, necessitate further mechanistic studies. PTK7 antibodies thus serve as critical reagents in both basic research and translational oncology.
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