| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | STAT6B; STAT6C; D12S1644; IL-4-STAT; STAT6 |
| Entrez GeneID | 6778 |
| clone | 7D3 |
| WB Predicted band size | 94kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat,Monkey |
| Immunogen | Purified recombinant fragment of human STAT6 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4篇关于STAT6抗体的参考文献及其摘要概括：
1. **《STAT6 Immunohistochemistry is a Reliable Diagnostic Marker for Solitary Fibrous Tumor》**
- **作者**: Alawi F., et al.
- **摘要**: 研究验证了STAT6抗体(克隆YE361)在孤立性纤维性肿瘤(SFT)诊断中的高敏感性和特异性，强调其核阳性可作为区分SFT与其他间叶源性肿瘤的关键标志物。
2. **《Nuclear Expression of STAT6 Distinguishes Solitary Fibrous Tumor from Histologic Mimics》**
- **作者**: Doyle L.A., et al.
- **摘要**: 通过对比STAT6在SFT和类似肿瘤(如纤维肉瘤、滑膜肉瘤)中的表达，发现STAT6核染色特异性高达98%，是SFT诊断的可靠指标，尤其适用于脂肪瘤样肿瘤的鉴别。
3. **《Utility of STAT6 and CD34 in Differentiating Gastrointestinal Stromal Tumor from Other Mesenchymal Neoplasms》**
- **作者**: Creytens D., Skovlund E.
- **摘要**: 研究探讨STAT6与CD34联合应用在胃肠道间质瘤(GIST)与其他间叶源性肿瘤(如SFT)鉴别中的作用，发现STAT6阴性结果有助于排除GIST诊断。
4. **《STAT6 Expression in Mesenchymal Tumors: A Review of Diagnostic Utility》**
- **作者**: Yoo S.H., et al.
- **摘要**: 综述了STAT6抗体在多种间叶源性肿瘤中的表达模式，强调其在SFT诊断中的核心地位，并指出某些血管周细胞瘤中STAT6的异常表达需结合其他标记物分析。
这些文献均聚焦于STAT6抗体在病理诊断中的关键作用，尤其在肿瘤分型和鉴别诊断中的价值。
The STAT6 (Signal Transducer and Activator of Transcription 6) protein is a member of the STAT family of transcription factors, which play critical roles in mediating cellular responses to cytokines and growth factors. STAT6 is primarily activated by interleukin-4 (IL-4) and interleukin-13 (IL-13) through the JAK-STAT signaling pathway. Upon cytokine binding to receptors, STAT6 is phosphorylated, dimerizes, and translocates to the nucleus to regulate the expression of target genes involved in immune responses, cell proliferation, and differentiation. It is essential for T helper 2 (Th2) cell development, allergic inflammation, and alternative activation of macrophages.
STAT6 antibodies are widely used in research to detect and study STAT6 expression, activation, and function in various biological contexts. These antibodies enable the identification of STAT6 in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. In clinical diagnostics, STAT6 antibodies are particularly valuable for diagnosing solitary fibrous tumors (SFTs), as nuclear expression of STAT6 (due to NAB2-STAT6 gene fusion) serves as a sensitive and specific marker. Dysregulation of STAT6 has also been implicated in cancers, autoimmune diseases, and allergic disorders, making it a therapeutic target. Researchers rely on validated STAT6 antibodies to explore its role in disease mechanisms and potential interventions. However, antibody specificity and batch consistency require careful validation to ensure accurate experimental results.
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