Mouse Monoclonal KLHL12 Antibody

The KLHL12 antibody is a research tool used to study the Kelch-like family member 12 (KLHL12) protein, a substrate adaptor for the Cullin 3 (CUL3)-based ubiquitin ligase complex. KLHL12 plays a critical role in regulating protein ubiquitination and degradation, influencing diverse cellular processes. Structurally, KLHL12 contains BTB and Kelch repeat domains, enabling interactions with target proteins and CUL3. It is notably involved in modulating the Wnt/β-catenin signaling pathway by promoting the ubiquitination of Dishevelled (Dvl) proteins, as well as regulating the secretion of collagen and other extracellular matrix components through interactions with SEC31. a COPII vesicle component. Dysregulation of KLHL12 has been implicated in pathologies such as cancer, fibrosis, and neurological disorders. Antibodies targeting KLHL12 are essential for detecting its expression, localization, and interactions in experimental models, including Western blotting, immunoprecipitation, and immunofluorescence. These tools help elucidate KLHL12’s role in cellular homeostasis, disease mechanisms, and potential therapeutic targets. Research using KLHL12 antibodies has advanced understanding of its dual functions in both developmental signaling and protein trafficking, highlighting its significance in maintaining cellular balance and disease pathogenesis.