| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | NKX3; BAPX2; NKX3A; NKX3.1; NKX3-1 |
| Entrez GeneID | 4824 |
| clone | 4H4 |
| WB Predicted band size | 26.3kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human NKX3A expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NKX3A抗体的3篇示例参考文献(注：以下文献信息为模拟示例，实际文献需通过学术数据库检索确认)：
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1. **文献名称**：*NKX3.1 as a Marker of Prostate Lineage and Tumor Suppression*
**作者**：Bowen, C., & Gelmann, E. P.
**摘要**：研究探讨了NKX3A(NKX3.1)作为前列腺特异性转录因子的功能，发现其在前列腺发育和肿瘤抑制中的作用。通过抗体免疫组化分析，证实NKX3A表达缺失与前列腺癌早期进展相关。
2. **文献名称**：*Loss of NKX3.1 Expression in Human Prostate Cancers Correlates with Tumor Grade*
**作者**：Gurel, B., et al.
**摘要**：利用NKX3A抗体对前列腺组织样本进行染色，发现NKX3A蛋白表达水平随肿瘤分级升高而降低，提示其作为前列腺癌诊断和分级的潜在生物标志物。
3. **文献名称**：*NKX3A in Tissue Regeneration and Cancer: A Dual Role*
**作者**：Shen, M. M., & Abate-Shen, C.
**摘要**：综述NKX3A在组织再生和癌症中的双重作用，强调其抗体在检测干细胞分化及肿瘤微环境研究中的应用，揭示其表达模式与组织修复异常的相关性。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“NKX3A antibody”、“NKX3.1 prostate cancer”获取最新研究。
The NKX3A antibody is a valuable tool in biomedical research, primarily used to study the NKX3.1 protein encoded by the NKX3A gene. NKX3A, a member of the NKX homeobox transcription factor family, plays a critical role in prostate development and maintenance. It regulates gene expression involved in cellular differentiation, apoptosis, and androgen signaling, and acts as a tumor suppressor in prostate tissue. Loss or reduced expression of NKX3A is associated with prostate carcinogenesis and disease progression.
NKX3A antibodies are widely employed in techniques like immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting to detect protein localization and expression levels in normal and pathological samples, particularly prostate cancer specimens. These antibodies help researchers investigate NKX3A's role in tissue-specific gene regulation, its interaction with signaling pathways (e.g., PI3K/AKT), and its potential as a biomarker for prostate cancer diagnosis or prognosis.
Commercially available NKX3A antibodies are typically raised in rabbits or mice, targeting specific epitopes within the protein. Validation includes testing in knockout cell lines or tissues to confirm specificity. Their application extends to studying NKX3A's involvement in other contexts, such as bladder or gastrointestinal cancers, though prostate research remains the primary focus. Understanding NKX3A dynamics via these antibodies contributes to insights into epithelial homeostasis and therapeutic targeting in oncology.
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