Mouse Monoclonal WNT5A Antibody

The WNT5A antibody is a crucial tool for studying the WNT5A protein, a member of the Wnt family of secreted glycoproteins involved in non-canonical Wnt signaling pathways, such as planar cell polarity and Wnt/Ca²⁺ signaling. WNT5A plays pivotal roles in embryonic development, cell migration, tissue patterning, and stem cell regulation. Dysregulation of WNT5A is linked to cancers (e.g., melanoma, breast, and gastric cancers), inflammatory diseases, and skeletal disorders, where it can act as either an oncogene or tumor suppressor depending on context. The antibody enables detection and quantification of WNT5A expression in cells and tissues via techniques like Western blot, immunohistochemistry (IHC), and immunofluorescence (IF). Both monoclonal and polyclonal variants target specific epitopes, aiding in functional studies to elucidate WNT5A's dual roles in disease progression and tissue homeostasis. Researchers use these antibodies to explore WNT5A's interaction with receptors like Frizzled and ROR2. its impact on metastatic potential, and its therapeutic targeting. Additionally, WNT5A antibodies are vital for evaluating its potential as a biomarker for prognosis or treatment response in cancers and bone-related pathologies. Their applications extend to drug development, where inhibiting or modulating WNT5A signaling could offer novel therapeutic strategies. Quality validation (e.g., knockout controls) ensures specificity, making these antibodies indispensable for advancing research in developmental biology, oncology, and regenerative medicine.