| WB | 咨询技术 | Human,Mouse,Rat,Rabbit |
| IF | 咨询技术 | Human,Mouse,Rat,Rabbit |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat,Rabbit |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat,Rabbit |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat,Rabbit |
| Elisa | 1/10000 | Human,Mouse,Rat,Rabbit |
| Aliases | TKT; MIG20a; NTRKR3; TYRO10 |
| Entrez GeneID | 4921 |
| clone | 3B11E4 |
| WB Predicted band size | 96.7kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat,Rabbit |
| Immunogen | Purified recombinant fragment of human DDR2 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与DDR2抗体相关的文献概览(注：以下为模拟示例，实际文献需通过数据库检索确认)：
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1. **文献名称**：*"A monoclonal antibody targeting DDR2 inhibits tumor growth in xenograft models"*
**作者**：Smith, J. et al. (2015)
**摘要**：本研究开发了一种针对DDR2胞外域的单克隆抗体，可特异性阻断DDR2与胶原的相互作用。实验显示该抗体在乳腺癌和肺癌小鼠模型中显著抑制肿瘤生长，提示其作为靶向治疗的潜力。
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2. **文献名称**：*"DDR2 expression in liver fibrosis and its modulation by anti-DDR2 neutralizing antibodies"*
**作者**：Chen, L. et al. (2017)
**摘要**：通过免疫组化及Western blot分析，发现DDR2在肝纤维化组织中高表达。使用中和抗体阻断DDR2活性后，可减少肝星状细胞活化及胶原沉积，表明DDR2抗体在抗纤维化治疗中的应用价值。
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3. **文献名称**：*"Development of a phospho-specific DDR2 antibody for studying kinase signaling in osteoarthritis"*
**作者**：Wang, Y. et al. (2019)
**摘要**：本研究设计了一种磷酸化特异性DDR2抗体，用于检测骨关节炎模型中DDR2的激活状态。该抗体验证了DDR2信号通路在软骨退变中的关键作用，并为疾病机制研究提供工具。
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**注意**：以上文献为示例性质，实际研究中请通过PubMed、Google Scholar等平台检索具体文献(关键词：DDR2 antibody, DDR2 inhibitor, discoidin domain receptor 2)以获取准确信息。
DDR2 (Discoidin Domain Receptor 2) is a transmembrane receptor tyrosine kinase (RTK) that plays a critical role in cell-matrix interactions. Unlike classical RTKs activated by growth factors, DDR2 is uniquely stimulated by binding to extracellular collagen, particularly types I–III fibrillar collagens. Structurally, DDR2 contains an extracellular discoidin domain for collagen recognition, a transmembrane domain, and an intracellular kinase domain responsible for downstream signaling. Upon collagen binding, DDR2 undergoes autophosphorylation, initiating signaling cascades (e.g., MAPK, PI3K/AKT) that regulate cell proliferation, differentiation, adhesion, and extracellular matrix remodeling.
DDR2 is implicated in both physiological processes (tissue development, wound healing) and pathological conditions. Dysregulation of DDR2 signaling has been linked to fibrosis, osteoarthritis, and cancer progression. In tumors, DDR2 promotes metastasis, epithelial-mesenchymal transition (EMT), and resistance to therapy by modulating tumor-stroma interactions. Its overexpression correlates with poor prognosis in breast, lung, and liver cancers.
DDR2 antibodies are essential tools for research and potential therapeutics. In research, they detect DDR2 expression in tissues or cell lines via techniques like Western blot, immunohistochemistry, or flow cytometry. Neutralizing antibodies or kinase inhibitors targeting DDR2 are being explored to block collagen-induced signaling in cancer and fibrotic diseases. Additionally, DDR2 antibodies may serve as diagnostic biomarkers for diseases involving collagen metabolism. However, challenges remain in developing isoform-specific antibodies due to structural similarities with DDR1. its closely related family member. Understanding DDR2's dual roles in health and disease continues to drive antibody-based studies for targeted therapies.
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