| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | FPS |
| Entrez GeneID | 2242 |
| clone | 2E3G3 |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of FES (AA:613-822)expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是关于FES抗体的3篇参考文献示例(文献信息为模拟生成，仅供参考)：
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1. **文献名称**：*The role of FES tyrosine kinase in cancer progression and therapeutic targeting*
**作者**：Smith A, et al.
**摘要**：研究利用FES特异性抗体分析了FES在多种癌细胞系中的表达，发现其通过调控STAT3信号通路促进肿瘤侵袭，为靶向治疗提供依据。
2. **文献名称**：*FES antibody-based detection of oncogenic mutations in acute myeloid leukemia*
**作者**：Chen L, et al.
**摘要**：通过FES抗体进行免疫沉淀和质谱分析，揭示了FES激酶结构域突变与白血病耐药性的关联，提示其作为预后标志物的潜力。
3. **文献名称**：*FES regulates macrophage differentiation via cytokine signaling pathways*
**作者**：Yamamoto K, et al.
**摘要**：使用FES抗体阻断实验证实FES通过调节IL-4/STAT6通路影响巨噬细胞极化，为免疫微环境研究提供新方向。
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注：以上文献为示例，实际引用时需查询真实数据库(如PubMed)获取准确信息。
The FES antibody targets the FES proto-oncogene (FES), a non-receptor tyrosine kinase encoded by the *FES* gene. Initially identified as the cellular homolog of v-fes, a transforming gene in feline sarcoma virus, FES plays roles in cell signaling, differentiation, and survival. It is particularly implicated in hematopoietic and epithelial cell regulation. FES kinase activity is modulated by phosphorylation and interactions with adaptor proteins, influencing pathways like MAPK and PI3K/AKT. Dysregulation of FES is linked to cancers, including leukemia and solid tumors, where it may act as both oncogene and tumor suppressor depending on context.
FES antibodies are critical tools for studying its expression, activation, and function. They enable detection via techniques like Western blot, immunohistochemistry, and flow cytometry, aiding research into FES's role in oncogenesis, immune response, and cellular development. Commercial FES antibodies are typically raised against specific epitopes, with validation in diverse experimental models. Recent studies explore FES inhibitors for targeted cancer therapies, underscoring its therapeutic relevance. Despite progress, challenges remain in understanding tissue-specific FES signaling and its dual roles in cancer, highlighting the continued importance of reliable FES antibodies in biomedical research. (Word count: 200)
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