关键信息
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基因名
CD63
- 应用
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别名
TSPAN30; LAMP-3; ME491; MLA1; OMA81H; Melanoma 1 antigen; Granulophysin; Lysosomal-associated membrane protein 3; Ocular melanoma-associated antigen
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08962
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表达区间
Ala103~Val203
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分子量
42kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
CD63 is a member of the tetraspanin family, which are integral membrane proteins that play crucial roles in cellular processes such as adhesion, migration, and signal transduction. As a prominent marker of exosomes and other extracellular vesicles, CD63 is implicated in various biological functions and disease states, notably in cancer progression and immune response. Research has highlighted its involvement in the formation of specialized microdomains in the plasma membrane, influencing cellular interactions and communication. Furthermore, CD63 has gained attention as a potential biomarker for identifying and characterizing exosomes derived from various cell types, including tumor cells, making it significant for diagnostic and therapeutic applications. The production of recombinant CD63 protein has become essential for elucidating its role in exosomal biology and for developing targeted therapies. Advances in protein engineering techniques have facilitated the generation of recombinant CD63, allowing for detailed studies into its structure, function, and interactions with other molecules. This knowledge is vital for understanding its mechanism in health and disease and for leveraging its properties in the development of innovative therapeutic strategies, such as drug delivery systems and cancer immunotherapies, that exploit the unique characteristics of exosomes displaying CD63. As research continues, elucidating the precise roles and mechanisms of CD63 could lead to significant breakthroughs in diagnostics and targeted treatments for various diseases, positioning it as a key player in innovative biotherapeutics.
