Recombinant Mouse Scgb1c1 protein

中文名： 分泌型珠蛋白家族1C成员1(Scgb1c1)重组蛋白
别名： Scgb1c1；Secretoglobin family 1C member 1

货号: PA2000-3184

Price： ￥询价

20μg 50μg 100μg ＞100μg

数量：

大包装询价

产品详情

纯度	>90%SDS-PAGE.
种属	Mouse
靶点	Scgb1c1
Uniprot No	Q7M742
内毒素	< 0.01EU/μg
表达宿主	E.coli
表达区间	24-95aa
氨基酸序列	EDDNEFFMEFLQTLLVGTPEELYEGPLGKYNVNDMAKSALRELKSCIDELQPVHKEQLVKLLVQVLDAQEDT
预测分子量	21.2 kDa
蛋白标签	His tag N-Terminus
缓冲液	PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
稳定性 & 储存条件	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

以下是关于Scgb1c1(Secretoglobin family 1C member 1)重组蛋白的参考文献示例，内容基于公开研究领域的方向概括。**建议通过PubMed或Google Scholar检索以获取真实文献**：

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1. **文献名称**: *"Recombinant expression and functional characterization of Scgb1c1 in modulating allergic airway inflammation"*

**作者**: Zhang Y, et al.

**摘要**: 研究团队在大肠杆菌系统中成功表达并纯化了重组Scgb1c1蛋白，通过小鼠模型证明该蛋白能够抑制Th2型免疫反应，减轻过敏性气道炎症，提示其作为潜在抗炎治疗分子的可能性。

2. **文献名称**: *"Structural insights into Scgb1c1-ligand interactions via recombinant protein crystallography"*

**作者**: Lee S, et al.

**摘要**: 利用昆虫细胞表达系统制备了高纯度Scgb1c1重组蛋白，并通过X射线晶体学解析其三维结构，揭示了其与疏水性配体(如前列腺素)结合的分子机制，为靶向药物设计提供依据。

3. **文献名称**: *"Scgb1c1 recombinant protein attenuates endometriosis progression by regulating lipid mediator synthesis"*

**作者**: Wang H, et al.

**摘要**: 研究通过哺乳动物细胞表达重组Scgb1c1.发现其通过调控花生四烯酸代谢途径，减少促炎性脂质介质(如PGE2)的合成，从而抑制子宫内膜异位症模型的病灶生长。

4. **文献名称**: *"Development of a high-yield Scgb1c1 recombinant protein production system in Pichia pastoris"*

**作者**: Kim J, et al.

**摘要**: 优化了毕赤酵母系统中Scgb1c1的分泌表达条件，实现了大规模高产量重组蛋白生产，并验证其生物活性与天然蛋白一致，为后续工业应用奠定基础。

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**注意**：以上文献为示例性概括，实际研究需参考具体发表的论文。推荐检索关键词：**Scgb1c1 recombinant protein, expression, function**。

背景信息

**Background of Scgb1c1 Recombinant Protein**

Secretoglobin family 1C member 1 (Scgb1c1) is a small, secreted protein belonging to the secretoglobin superfamily, characterized by conserved structural motifs and roles in modulating inflammation, immune responses, and lipid interactions. Though its precise biological function remains less defined compared to well-studied members like Scgb1a1 (CCSP/CC10), Scgb1c1 is hypothesized to play regulatory roles in mucosal immunity, particularly in respiratory or reproductive tissues, where secretoglobins are often highly expressed.

Recombinant Scgb1c1 protein is engineered using heterologous expression systems (e.g., *E. coli*, mammalian cells*) to produce purified, functional protein for research. Its production enables studies on structure-function relationships, ligand-binding properties (e.g., to lipids or steroids), and interactions with immune cells or signaling molecules. Scgb1c1 may act as an anti-inflammatory mediator, akin to other secretoglobins, by suppressing cytokine activity or oxidative stress.

Interest in Scgb1c1 also stems from its potential relevance in disease models, such as asthma, chronic obstructive pulmonary disease (COPD), or cancers, where dysregulated secretoglobin expression is observed. Recombinant variants facilitate antibody development, biomarker discovery, and therapeutic exploration. However, challenges include elucidating tissue-specific roles and resolving structural details due to its low molecular weight (~10-12 kDa) and dimeric quaternary structure.

Overall, Scgb1c1 recombinant protein serves as a critical tool for unraveling its physiological significance and translational potential in inflammatory and immune-related pathologies.