关键信息
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基因名
TM4SF2/TSPAN7
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简介
TM4SF2/TSPAN7 Protein is a member of the tetraspanin family. It mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TSPAN7 promotes apoptosis and inhibits tumor growth and cell cycle progression in BCa via the regulation of multiple key components of the PTEN/PI3K/AKT pathway. During cell differentiation, TSPAN7 emerges as a master regulator of morphological changes through cytoskeletal remodeling. TM4SF2/TSPAN7 Protein, Human (HEK293, His) is the recombinant human-derived TM4SF2/TSPAN7 protein, expressed by HEK293 , with C-His labeled tag.
- 应用
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别名
Tetraspanin-7; Tspan-7; CD231; Mxs1; Tm4sf2
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种属
Human
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
AAH18036.1
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表达区间
R113-M213
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分子量
21-30 kDa due to glycosylation
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
TM4SF2 (Transmembrane 4 LSix Family Member 2) and TSPAN7 (Tetraspanin 7) are members of the tetraspanin superfamily, known for their role in cell membrane dynamics and interactions. These proteins participate in various cellular processes, including cell signaling, adhesion, and migration, which are critical in both normal physiological functions and pathological conditions such as cancer and neurodegenerative diseases. Recent studies have implicated TM4SF2 in liver fibrogenesis and cancer progression, while TSPAN7 has been linked to neuronal cell signaling and cognitive functions. The investigation of TM4SF2/TSPAN7 recombinant proteins is crucial for understanding their individual and cooperative roles in cellular contexts. The recombinant expression of these proteins allows for the elucidation of their structural and functional properties, enabling researchers to study their interactions with other membrane proteins and their involvement in signal transduction pathways. Furthermore, understanding how these proteins affect cellular behaviors can provide insights into their potential as therapeutic targets. The exploration of TM4SF2 and TSPAN7 through recombinant technology not only enhances our comprehension of their biological functions but also opens avenues for developing novel strategies to modulate their activity in disease contexts.
