关键信息
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基因名
Nectin-2/CD112
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简介
Nectin-2/CD112 protein has dual roles in T-cell signaling: as a costimulator with CD226, promoting proliferation and cytokine production, and as a coinhibitor with PVRIG, inhibiting proliferation. It also acts as a cell adhesion protein and a receptor for certain viruses. Nectin-2/CD112 Protein, Human (Biotinylated, HEK293, mFc-Avi) is the recombinant human-derived Nectin-2/CD112 protein, expressed by HEK293 , with C-Avi, C-mFc labeled tag. The total length of Nectin-2/CD112 Protein, Human (Biotinylated, HEK293, mFc-Avi) is 329 a.a., with molecular weight of 70-90 kDa.
- 应用
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别名
CD112; Nectin-2; PVRL2
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种属
Human
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表达系统
HEK293
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标签
C-Avi;C-mFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92692-2
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表达区间
Q32-L360
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分子量
70-90 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Nectin-2, also known as CD112, is a member of the Nectin family, which comprises immunoglobulin-like cell adhesion molecules. It plays a crucial role in cellular interactions, including cell adhesion and migration, and is involved in various physiological and pathological processes, such as immune response and tumor progression. The expression of Nectin-2 has been observed in multiple types of tumors, where it facilitates immune evasion by interacting with the DNAM-1 receptor on natural killer (NK) cells and T cells, thereby inhibiting their cytotoxic functions. Consequently, Nectin-2 has garnered attention as a potential target for cancer immunotherapy. Researchers are focused on the development of recombinant Nectin-2/CD112 proteins to better understand its biological functions and to create therapeutic strategies that can block its immunosuppressive effects. These recombinant proteins can also be utilized in the study of Nectin-2's role in tumor biology, as well as in the development of Nectin-2-targeted therapies, such as monoclonal antibodies or fusion proteins. By elucidating the mechanisms by which Nectin-2 modulates immune responses, scientists aim to enhance the effectiveness of cancer immunotherapies and improve patient outcomes.
