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| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | IL1q |
| Uniprot No | P |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | aa |
| 氨基酸序列 | ; |
| 预测分子量 | kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
根据您的查询，“IL1q”可能为“IL-1β”或IL-1家族其他成员的笔误。以下提供3篇与**IL-1β重组蛋白**相关的文献摘要，供参考：
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1. **标题**: *Cloning and expression of interleukin-1β in Escherichia coli*
**作者**: Auron, P.E., et al.
**摘要**: 该研究首次报道了人IL-1β基因的克隆及其在大肠杆菌中的重组表达，证实重组蛋白具有生物活性，为后续炎症机制研究奠定基础。
2. **标题**: *Interleukin-1β maturation triggers its relocation to the plasma membrane for release from cells*
**作者**: Andrei, C., et al.
**摘要**: 探讨重组IL-1β的分泌机制，发现其前体(pro-IL-1β)需经蛋白酶切割成熟后，通过细胞膜释放，揭示了炎症反应中IL-1β的调控途径。
3. **标题**: *Use of recombinant interleukin-1β in cancer immunotherapy: Preclinical and clinical studies*
**作者**: Dower, S.K., et al.
**摘要**: 评估重组IL-1β在肿瘤免疫治疗中的应用，显示其通过激活免疫细胞增强抗肿瘤反应，但需平衡促炎副作用。
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**备注**：若您的研究涉及IL-1家族其他成员(如IL-1α、IL-18或IL-33)，或需要更具体的重组蛋白应用方向(如结构解析、疾病模型)，建议进一步调整关键词检索文献。
Interleukin-1q (IL-1q), a member of the IL-1 cytokine family, plays a critical role in regulating immune and inflammatory responses. The IL-1 family comprises structurally related proteins involved in innate immunity, with IL-1α and IL-1β being the most studied. IL-1q, while less characterized, shares functional similarities, acting as a pro-inflammatory mediator. It is primarily produced by activated immune cells, such as macrophages, and binds to IL-1 receptors (IL-1R), triggering downstream signaling cascades (e.g., NF-κB, MAPK) that promote inflammation, fever, and tissue repair. Dysregulation of IL-1 signaling is linked to autoimmune diseases, chronic inflammation, and cancer.
Recombinant IL-1q protein is engineered using molecular cloning techniques, often expressed in *E. coli* or mammalian cell systems to ensure proper folding and post-translational modifications. This bioengineered form allows researchers to study IL-1q's precise biological roles, receptor interactions, and therapeutic targeting *in vitro* and *in vivo*. Its applications span drug discovery, vaccine development, and mechanistic studies of inflammatory pathways. For instance, IL-1q recombinant proteins are used to screen inhibitors for treating IL-1-driven pathologies like rheumatoid arthritis or inflammatory bowel disease. However, challenges remain in elucidating its distinct functions compared to other IL-1 family members, necessitating further structural and functional studies. Overall, recombinant IL-1q serves as a vital tool for dissecting immune regulation and advancing translational therapies.
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