| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | IGBP1 |
| Uniprot No | P78318 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 2-339aa |
| 氨基酸序列 | AAEDELQLP RLPELFETGR QLLDEVEVAT EPAGSRIVQE KVFKGLDLLE KAAEMLSQLD LFSRNEDLEE IASTDLKYLL VPAFQGALTM KQVNPSKRLD HLQRAREHFI NYLTQCHCYH VAEFELPKTM NNSAENHTAN SSMAYPSLVA MASQRQAKIQ RYKQKKELEH RLSAMKSAVE SGQADDERVR EYYLLHLQRW IDISLEEIES IDQEIKILRE RDSSREASTS NSSRQERPPV KPFILTRNMA QAKVFGAGYP SLPTMTVSDW YEQHRKYGAL PDQGIAKAAP EEFRKAAQQQ EEQEEKEEED DEQTLHRARE WDDWKDTHPR GYGNRQNMG |
| 预测分子量 | kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于IGBP1重组蛋白的3篇参考文献及其摘要概括：
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1. **文献名称**: *Production and Characterization of Recombinant IGBP1 for Functional Studies in B-Cell Signaling*
**作者**: Chen L, Wang H, et al.
**摘要**: 本研究利用大肠杆菌表达系统成功表达并纯化了重组IGBP1蛋白，验证其与免疫球蛋白(IgG)的结合能力。实验表明，重组IGBP1通过调控B细胞受体信号通路，影响B细胞的增殖与分化，为免疫调节机制研究提供工具。
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2. **文献名称**: *Structural Insights into IGBP1 Interaction with Fc Region of IgG*
**作者**: Kumar S, Gupta R, et al.
**摘要**: 通过X射线晶体学解析了重组人源IGBP1与IgG-Fc片段的复合物结构，揭示了IGBP1特异性结合IgG的关键氨基酸位点。此发现为开发基于IGBP1的抗体纯化技术或免疫疗法奠定结构基础。
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3. **文献名称**: *IGBP1 as a Potential Biomarker in Autoimmune Diseases: Recombinant Protein-Based Assay Development*
**作者**: Martinez E, Lee J, et al.
**摘要**: 研究构建了重组IGBP1蛋白的ELISA检测体系，发现类风湿性关节炎患者血清中IGBP1水平显著升高，提示其可能作为自身免疫疾病的诊断标志物，并探讨了其在病理中的潜在作用机制。
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注：以上文献信息为示例性内容，实际研究中需根据具体论文补充。建议通过PubMed或Google Scholar检索关键词“recombinant IGBP1”获取真实文献。
**Background of IGBP1 Recombinant Protein**
Immunoglobulin Binding Protein 1 (IGBP1), also known as Immunoglobulin Gamma Binding Protein 1. is a member of the B-cell receptor (BCR) signalosome complex. It plays a critical role in regulating B-cell receptor signaling by interacting with key components such as CD79A and CD79B, which are essential for B-cell development, survival, and antigen presentation. IGBP1 is involved in modulating the internalization and degradation of the BCR, thereby influencing immune response dynamics. Dysregulation of IGBP1 has been linked to autoimmune disorders and B-cell malignancies, highlighting its importance in both physiological and pathological contexts.
Recombinant IGBP1 protein is engineered using advanced molecular cloning techniques, typically expressed in prokaryotic (e.g., *E. coli*) or eukaryotic (e.g., mammalian or insect cell) systems to ensure proper folding and post-translational modifications. The recombinant form retains the functional epitopes of the native protein, enabling its use in structural studies, interaction assays, and functional analyses. It is commonly purified via affinity tags (e.g., His-tag) and validated for activity through methods like ELISA, Western blot, or surface plasmon resonance (SPR).
Research applications of recombinant IGBP1 include elucidating BCR signaling pathways, studying immune tolerance mechanisms, and screening therapeutic agents targeting B-cell-related diseases. Its availability in recombinant form accelerates experimental reproducibility and reduces variability compared to isolating the protein from native sources. Additionally, it serves as a vital tool for developing diagnostic assays or immunotherapies aimed at modulating B-cell activity.
In summary, recombinant IGBP1 is a versatile reagent that bridges basic immunology research and translational medicine, offering insights into B-cell biology and potential therapeutic strategies.
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