关键信息
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基因名
STAG1
- 应用
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别名
Cohesin subunit SA 1; Cohesin subunit SA-1; Cohesin Subunit SA1; Nuclear protein stromal antigen 1; SA 1; SCC 3 homolog 1; Scc3; SCC3 homolog 1; STAG 1; stag1; STAG1_HUMAN; Stromal antigen 1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WVM7
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表达区间
181-280 aa
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氨基酸序列
NRTIFDSDLMDSARLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYPGSSFQHQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL
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分子量
36.74 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
STAG1 (Sister Telomere Associated Gene 1) is a member of the STAG family of proteins, which play crucial roles in the cohesion of sister chromatids during cell division. This protein is essential for the proper functioning of the cohesin complex, responsible for maintaining the integrity of chromosomes and regulating their segregation during mitosis and meiosis. Research has demonstrated that STAG1 is involved in various cellular processes, including DNA repair, chromosomal stability, and gene expression regulation. Mutations or dysregulation of STAG1 have been linked to several cancers, highlighting its potential importance in tumorigenesis. As a result, understanding the structure and function of STAG1 through the study of its recombinant protein is vital for elucidating its role in cell division and pathology. This research can facilitate the development of targeted therapies and biomarkers for cancer treatment by providing insights into the molecular mechanisms underpinning chromosomal abnormalities and their contributions to malignancies. Moreover, recombinant STAG1 protein can be employed in biochemical assays and structural studies to explore its interactions with other cellular components, furthering our understanding of cohesin's role in genome stability.
