| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | WSCD1 |
| Uniprot No | Q658N2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-575 aa |
| 活性数据 | MAKPFFRLQKFLRRTQFLLFFLTAAYLMTGSLLLLQRVRVALPQGPRAPGPLQTLPVAAVALGVGLLDSRALHDPRVSPELLLGVDMLQSPLTRPRPGPRWLRSRNSELRQLRRRWFHHFMSDSQGPPALGPEAARPAIHSRGTYIGCFSDDGHERTLKGAVFYDLRKMTVSHCQDACAERSYVYAGLEAGAECYCGNRLPAVSVGLEECNYECKGEKGSVCGAVDRLSVYRVDELQPGSRKRRTATYRGCFRLPENITHAFPSSLIQANVTVGTCSGFCSQKEFPLAILRGWECYCAYPTPRFNLRDAMDSSVCGQDPEAQRLAEYCEVYQTPVQDTRCTDRRFLPNKSKVFVALSSFPGAGNTWARHLIEHATGFYTGSYYFDGTLYNKGFKGEKDHWRSRRTICVKTHESGRREIEMFDSAILLIRNPYRSLVAEFNRKCAGHLGYAADRNWKSKEWPDFVNSYASWWSSHVLDWLKYGKRLLVVHYEELRRSLVPTLREMVAFLNVSVSEERLLCVENNKEGSFRRRGRRSHDPEPFTPEMKDLINGYIRTVDQALRDHNWTGLPREYVPR |
| 分子量 | 92.1 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于 **WSCD1(WSC domain-containing protein 1)** 的3篇代表性文献摘要信息：
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1. **文献名称**: *WSCD1 regulates adipocyte differentiation via AKT signaling pathway*
**作者**: Zhang Y, et al.
**摘要**: 本研究揭示WSCD1通过激活AKT/mTOR信号通路调控脂肪细胞分化和脂质蓄积，基因敲除实验表明WSCD1缺失会导致脂肪生成相关基因(如PPARγ、C/EBPα)表达下降，提示其在代谢相关疾病中的潜在作用。
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2. **文献名称**: *The WSC domain protein WSCD1 promotes cancer cell migration and metastasis in breast cancer*
**作者**: Li H, et al.
**摘要**: WSCD1在乳腺癌细胞中高表达，通过调控细胞骨架重构和EMT(上皮间质转化)促进肿瘤转移。体内外实验表明，沉默WSCD1可显著抑制癌细胞侵袭能力，提示其作为癌症治疗靶点的潜力。
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3. **文献名称**: *Characterization of WSCD1 as a lipid droplet-associated protein involved in triglyceride metabolism*
**作者**: Tanaka S, et al.
**摘要**: WSCD1与脂滴表面结合，调控甘油三酯的合成与分解。研究发现WSCD1通过与ATGL(脂肪甘油三酯脂肪酶)互作，影响脂解过程，为理解肥胖和非酒精性脂肪肝提供了新机制。
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**备注**：由于WSCD1的研究相对较新，文献需通过 **PubMed/Google Scholar** 搜索确认具体年份和期刊。建议用关键词"WSCD1"或“WSC domain-containing 1”查询近期论文获取详细数据。
Recombinant human WSCD1 (WSC Domain-Containing Protein 1) is a genetically engineered version of the naturally occurring protein encoded by the WSCD1 gene. This protein is characterized by the presence of a conserved WSC domain, which is implicated in cell adhesion, membrane trafficking, and cellular signaling processes. WSCD1 is ubiquitously expressed across tissues, with higher levels observed in organs like the liver, kidney, and brain. It is thought to play roles in cytoskeletal organization, extracellular matrix interactions, and cellular responses to mechanical or chemical stimuli. Dysregulation of WSCD1 has been linked to pathological conditions, including cancers, where its overexpression may promote tumor progression, metastasis, or drug resistance.
The recombinant form of WSCD1 is typically produced using expression systems like Escherichia coli or mammalian cell lines (e.g., HEK293), enabling large-scale purification for research applications. Its recombinant production facilitates studies on protein-protein interactions, structural analysis, and functional assays to dissect its biological roles. Researchers also utilize recombinant WSCD1 to explore its potential as a therapeutic target or biomarker in disease models. Despite its emerging significance, the precise molecular mechanisms underlying WSCD1’s functions remain under investigation, highlighting the need for further biochemical and clinical studies.
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