| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TRGV3 |
| Uniprot No | P03979 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 21-136 aa |
| 活性数据 | NLEGRTKSVT RQTGSSAEIT CDLTVTNTFY IHWYLHQEGK APQRLLYYDV STARDVLESG LSPGKYYTHT PRRWSWILRL QNLIENDSGV YYCATWDRXK NYYKKLFGSG TTLVVT |
| 分子量 | 13.6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于重组人TRGV3蛋白的示例参考文献(格式为文献名称、作者、摘要简述)：
1. **"Structural analysis of the T cell receptor gamma variable domain TRGV3 in human γδ T cells"**
*Author: Smith A, et al.*
摘要：研究利用重组TRGV3蛋白解析了其晶体结构，揭示了其独特的抗原结合构象，并探讨了该区域在γδ T细胞识别病原体中的功能特性。
2. **"Recombinant expression and functional characterization of TRGV3 in autoimmune disorders"**
*Author: Lee JH, et al.*
摘要：通过大肠杆菌系统成功表达可溶性TRGV3蛋白，并证实其与特定自身抗原的结合能力，为研究TRGV3在自身免疫疾病中的潜在作用提供了工具。
3. **"TRGV3 as a biomarker: Development of a recombinant protein-based assay for cancer detection"**
*Author: Wang Q, et al.*
摘要：构建重组TRGV3蛋白用于血清学检测，发现其在多种癌症患者中表达异常，提示其作为肿瘤诊断标志物的可能性。
4. **"TRGV3-mediated signaling pathways in innate immunity"**
*Author: Gupta R, et al.*
摘要：通过体外重组TRGV3蛋白实验，揭示了该蛋白通过激活NF-κB通路增强γδ T细胞的先天免疫应答机制。
注：以上为模拟文献摘要，实际研究中请通过PubMed或Web of Science检索具体文献。TRGV3的研究相对较少，建议扩展至T细胞受体γ链(TRG)家族或γδ T细胞相关领域。
**Background of Recombinant Human TRGV3 Protein**
The T-cell receptor gamma variable 3 (TRGV3) protein is a component of the gamma-delta (γδ) T-cell receptor (TCR), a critical immune receptor expressed on γδ T cells. These cells bridge innate and adaptive immunity, playing roles in pathogen defense, tumor surveillance, and tissue homeostasis. TRGV3. encoded by the TRGV3 gene within the T-cell receptor gamma locus, forms part of the variable (V) domain of the TCR γ chain. This domain contributes to antigen recognition, enabling γδ T cells to detect diverse antigens, including stress-induced molecules and microbial components, without requiring MHC presentation.
Recombinant TRGV3 protein is produced using biotechnological methods, such as expression in mammalian or bacterial systems, to study its structural and functional properties. Research focuses on its role in γδ TCR assembly, ligand binding, and activation mechanisms. Additionally, recombinant TRGV3 aids in developing γδ T cell-based immunotherapies, leveraging their ability to target cancers and infections. Its study also sheds light on TCR diversity, immune regulation, and potential therapeutic targets for autoimmune diseases or immune deficiencies.
As a non-invariant γδ TCR component, TRGV3 highlights the adaptability of γδ T cells in immune responses, making it a key focus in translational immunology.
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