| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TRDV2 |
| Uniprot No | A0JD36 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 20-115 aa |
| 活性数据 | AIELVPEHQTVPVSIGVPATLRCSMKGEAIGNYYINWYRKTQGNTMTFIYREKDIYGPGFKDNFQGDIDIAKNLAVLKILAPSERDEGSYYCACDT |
| 分子量 | 12.9 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人TRDV2蛋白的3篇参考文献示例(注：文献为虚构，仅供示例参考)：
1. **文献名称**：*Expression and Purification of Recombinant Human TRDV2 Protein in Mammalian Cells*
**作者**：Smith A. et al.
**摘要**：该研究描述了在HEK293细胞中高效表达及纯化重组人TRDV2蛋白的方法，并验证了其与γδ T细胞表面受体复合物的结合能力，为研究TRDV2的功能提供了工具。
2. **文献名称**：*Structural Insights into TRDV2-mediated Antigen Recognition*
**作者**：Zhang Y. et al.
**摘要**：通过X射线晶体学解析TRDV2蛋白的三维结构，揭示了其与特定抗原结合的分子机制，表明其在抗感染免疫中的潜在应用价值。
3. **文献名称**：*TRDV2+ T Cells in Cancer Immunotherapy: Functional Characterization of Recombinant TRDV2*
**作者**：Johnson R. et al.
**摘要**：研究发现表达TRDV2的γδ T细胞能特异性识别肿瘤细胞表面抗原，重组TRDV2蛋白可增强T细胞活化，为基于TRDV2的免疫疗法提供了实验依据。
*注：以上文献为示例性内容，实际研究请参考真实数据库(如PubMed)中的发表论文。*
**Background of Recombinant Human TRDV2 Protein**
The T-cell receptor delta variable 2 (TRDV2) protein is a component of the gamma-delta (γδ) T-cell receptor (TCR), a unique subset of T lymphocytes that bridge innate and adaptive immunity. Unlike conventional alpha-beta (αβ) T cells, γδ T cells recognize antigens in a major histocompatibility complex (MHC)-independent manner, enabling rapid responses to stress signals, pathogens, and tumor antigens. TRDV2 is part of the variable domain of the δ chain, contributing to the diversity of antigen recognition.
Recombinant TRDV2 protein is engineered *in vitro* using molecular cloning techniques, often expressed in systems like *E. coli* or mammalian cells, followed by purification for research or therapeutic applications. It serves as a critical tool to study γδ T-cell biology, including ligand interactions, TCR signaling, and immune modulation. TRDV2 has garnered interest in immunotherapy due to its role in targeting malignancies and infected cells. Additionally, recombinant TRDV2 aids in developing bispecific antibodies or engineered TCR therapies, enhancing specificity for cancer antigens. Studies also explore its diagnostic potential in autoimmune diseases and infections. By elucidating TRDV2’s structural and functional properties, researchers aim to harness γδ T cells' unique capabilities for innovative immune-based treatments.
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