| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MEF2BNB |
| Uniprot No | Q96FH0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-119aa |
| 活性数据 | MEEPEMQLKG KKVTDKFTES VYVLANEPSV ALYRLQEHVR RSLPELAQHK ADMQRWEEQS QGAIYTVEYA CSAVKNLVDS SVYFRSVEGL LKQAISIRDH MNASAQGHSP EEPPPPSSA |
| 分子量 | 13,4 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人MEF2BNB蛋白的虚构参考文献示例(仅供格式参考，实际文献可能需进一步核实)：
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1. **文献名称**: "Expression and Functional Analysis of Recombinant Human MEF2BNB Protein in Cardiomyocyte Development"
**作者**: Zhang L et al.
**摘要**: 本研究报道了通过大肠杆菌系统高效表达重组人MEF2BNB蛋白的纯化方法，并验证其在心肌细胞分化中的调控作用。研究发现，该蛋白通过结合特定DNA序列激活下游肌肉特异性基因表达。
2. **文献名称**: "Structural Characterization of MEF2BNB and Its Interaction with HDAC4 in Neuronal Cells"
**作者**: Thompson R et al.
**摘要**: 利用X射线晶体学解析重组人MEF2BNB蛋白的三维结构，揭示其与组蛋白去乙酰化酶HDAC4的结合位点，为神经退行性疾病中MEF2BNB的功能障碍提供分子机制依据。
3. **文献名称**: "MEF2BNB Recombinant Protein Attenuates Inflammation in Macrophages via NF-κB Pathway"
**作者**: Kim S et al.
**摘要**: 研究发现重组MEF2BNB蛋白可通过抑制NF-κB信号通路降低巨噬细胞的炎症因子释放，提示其作为潜在抗炎治疗分子的应用价值。
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**注意**：以上内容为模拟生成，MEF2BNB蛋白名称可能为虚构或书写变体。实际研究中请通过学术数据库(如PubMed、Google Scholar)检索具体文献，并核实基因/蛋白名称的正确性(如是否为MEF2B或MEF2家族其他成员)。
Recombinant human MEF2BNB protein is a genetically engineered version of the myocyte enhancer factor 2B (MEF2B) protein, part of the MEF2 transcription factor family. MEF2 proteins (MEF2A, B, C, D) regulate gene expression by binding conserved DNA sequences, playing critical roles in cellular differentiation, development, and stress responses. MEF2B, encoded by the *MEF2B* gene, contains a MADS-box domain for DNA binding and a MEF2-specific domain for protein interactions. It is notably involved in B-cell proliferation, neuronal survival, and cardiac muscle regulation. Dysregulation of MEF2B is linked to immune disorders, cardiovascular diseases, and cancers, particularly diffuse large B-cell lymphoma. The recombinant form, produced via bacterial or mammalian expression systems, allows researchers to study its molecular mechanisms, post-translational modifications (e.g., phosphorylation, acetylation), and interactions with co-regulators like histone deacetylases. Its applications span structural biology, drug screening, and disease modeling. By providing a purified, functional protein, MEF2BNB aids in exploring therapeutic strategies targeting MEF2 pathways in cancer immunotherapy or neurodegenerative diseases. Additionally, it serves as a tool for antibody development and diagnostic assays. Research on this protein enhances understanding of its dual roles in health and pathology, bridging fundamental biology with translational medicine.
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