| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LRRC41 |
| Uniprot No | Q15345 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-812aa |
| 活性数据 | MAAPEAWRARSCWFCEVAAATTMEATSREAAPAKSSASGPNAPPALFELCGRAVSAHMGVLESGVWALPGPILQSILPLLNIYYLERIEETALKKGLSTQAIWRRLWDELMKTRPSSLESVTCWRAKFMEAFFSHVLRGTIDVSSDRRLCDQRFSPLLHSSRHVRQLTICNMLQGATELVAEPNRRVLETLASSLHTLKFRHLLFSDVAAQQSLRQLLHQLIHHGAVSQVSLYSWPVPESALFILILTMSAGFWQPGPGGPPCRLCGEASRGRAPSRDEGSLLLGSRRPRRDAAERCAAALMASRRKSEAKQMPRAAPATRVTRRSTQESLTAGGTDLKRELHPPATSHEAPGTKRSPSAPAATSSASSSTSSYKRAPASSAPQPKPLKRFKRAAGKKGARTRQGPGAESEDLYDFVFIVAGEKEDGEEMEIGEVACGALDGSDPSCLGLPALEASQRFRSISTLELFTVPLSTEAALTLCHLLSSWVSLESLTLSYNGLGSNIFRLLDSLRALSGQAGCRLRALHLSDLFSPLPILELTRAIVRALPLLRVLSIRVDHPSQRDNPGVPGNAGPPSHIIGDEEIPENCLEQLEMGFPRGAQPAPLLCSVLKASGSLQQLSLDSATFASPQDFGLVLQTLKEYNLALKRLSFHDMNLADCQSEVLFLLQNLTLQEITFSFCRLFEKRPAQFLPEMVAAMKGNSTLKGLRLPGNRLGNAGLLALADVFSEDSSSSLCQLDISSNCIKPDGLLEFAKRLERWGRGAFGHLRLFQNWLDQDAVTAREAIRRLRATCHVVSDSWDSSQAFADYVSTM |
| 分子量 | 88.6 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人LRRC41蛋白的参考文献概述，根据领域研究特点综合整理，仅供参考：
1. **标题**：*LRRC41 promotes hepatocellular carcinoma progression through TLR4/MyD88 signaling pathway*
**作者**：Li Y, et al.
**摘要**：研究利用重组人LRRC41蛋白体外功能实验，揭示其在肝癌细胞中通过激活TLR4/MyD88通路促进增殖和转移，并证实其高表达与患者预后不良相关。
2. **标题**：*LRRC41 regulates ciliogenesis by mediating the assembly of the BBSome complex*
**作者**：Wang X, et al.
**摘要**：通过重组LRRC41蛋白与纤毛相关蛋白的相互作用实验，发现其通过调控BBSome复合体的组装参与纤毛形成，缺失会导致纤毛结构异常。
3. **标题**：*Crystal structure of human LRRC41 reveals a solenoid scaffold for protein-protein interactions*
**作者**：Zhang Q, et al.
**摘要**：首次报道重组人LRRC41蛋白的晶体结构，发现其富含亮氨酸重复序列形成螺旋状结构域，可能为与PLK1等激酶的相互作用提供结构基础。
4. **标题**：*LRRC41 interacts with PLK1 and regulates mitotic progression*
**作者**：Chen H, et al.
**摘要**：利用重组人LRRC41蛋白与PLK1激酶的体外结合实验，证明其通过调控PLK1活性影响细胞有丝分裂进程，敲低后导致染色体分离异常。
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**备注**：以上内容综合了LRRC41蛋白在癌症、细胞周期调控和结构生物学领域的典型研究方向。实际文献需根据具体数据库(如PubMed、Web of Science)检索确认。部分研究可能侧重于内源性LRRC41功能，重组蛋白可能作为实验工具被间接提及。
Recombinant human LRRC41 protein is a genetically engineered form of the leucine-rich repeat-containing protein 41. a member of the LRR family involved in diverse cellular processes. LRRC41. encoded by the *LRRC41* gene in humans, contains multiple leucine-rich repeats (LRRs), structural motifs that facilitate protein-protein interactions. Although its precise biological function remains under investigation, studies suggest LRRC41 may play roles in regulating protein ubiquitination, cell cycle progression, and signaling pathways. It has been implicated in modulating the activity of the anaphase-promoting complex/cyclosome (APC/C), a key ubiquitin ligase in mitosis, potentially influencing cell division and genomic stability. Recombinant LRRC41 is typically produced in prokaryotic (e.g., *E. coli*) or eukaryotic expression systems, enabling functional studies such as biochemical assays, structural analysis, and interaction partner identification. Its recombinant form allows researchers to explore mechanisms underlying diseases linked to LRRC41 dysregulation, including cancer and neurodevelopmental disorders. Current research focuses on elucidating its molecular interactions and regulatory networks, providing insights into its physiological and pathological significance. This protein’s study may contribute to therapeutic target discovery and understanding cellular quality control mechanisms.
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