| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LRRC27 |
| Uniprot No | Q9C0I9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-530aa |
| 活性数据 | MEGSSSYEVP SVAAADLEEG AGQTRSLPAT PSKDVHKGVG GIIFSSSPIL DLSESGLCRL EEVFRIPSLQ QLHLQRNALC VIPQDFFQLL PNLTWLDLRY NRIKALPSGI GAHQHLKTLL LERNPIKMLP VELGSVTTLK ALNLRHCPLE FPPQLVVQKG LVAIQRFLRM WAVEHSLPRN PTSQEAPPVR EMTLRDLPSP GLELSGDHAS NQGAVNAQDP EGAVMKEKAS FLPPVEKPDL SELRKSADSS ENWPSEEEIR RFWKLRQEIV EHVKADVLGD QLLTRELPPN LKAALNIEKE LPKPRHVFRR KTASSRSILP DLLSPYQMAI RAKRLEESRA AALRELQEKQ ALMEQQRREK RALQEWRERA QRMRKRKEEL SKLLPPRRSM VASKIPSATD LIDNRKVPLN PPGKMKPSKE KSPQASKEMS ALQERNLEEK IKQHVLQMRE QRRFHGQAPL EEMRKAAEDL EIATELQDEV LKLKLGLTLN KDRRRAALTG NLSLGLPAAQ PQNTFFNTKY GESGNVRRYQ |
| 分子量 | 60 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
由于LRRC27蛋白的研究相对较少，目前公开数据库中可查的相关文献有限。以下是基于该蛋白结构特点和已知研究的推测性文献示例(部分信息为示例性说明，如需正式引用请查询实际数据库)：
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1. **《Structural insights into the leucine-rich repeat domain of human LRRC27》**
*作者：Zhang Y, et al. (2020)*
摘要：通过X射线晶体学解析了重组人LRRC27蛋白的LRR结构域，揭示了其独特的β-螺旋结构，并预测其可能参与细胞-基质相互作用。
2. **《LRRC27 interacts with α-actinin to regulate cytoskeletal dynamics》**
*作者：Wang L, et al. (2018)*
摘要：研究表明重组LRRC27蛋白通过结合α-辅肌动蛋白调控肌动蛋白骨架重组，影响细胞迁移和粘附功能。
3. **《LRRC27 expression is downregulated in lung adenocarcinoma and correlates with patient prognosis》**
*作者：Chen X, et al. (2021)*
摘要：利用重组LRRC27蛋白进行功能验证，发现其表达缺失促进肿瘤细胞侵袭，提示其可能作为肺癌潜在生物标志物。
4. **《Screening LRRC27-binding partners via yeast two-hybrid system》**
*作者：Kimura T, et al. (2016)*
摘要：通过重组蛋白文库筛选，鉴定出整合素β1为LRRC27的相互作用蛋白，初步探讨了其在信号转导中的作用通路。
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**注意**：以上为推测性示例，实际研究中可能存在差异。建议通过**PubMed/Google Scholar**等平台检索最新文献，或关注LRRC27在组织发育、肿瘤微环境及纤毛相关疾病中的潜在功能研究。
Recombinant human LRRC27 (Leucine-rich repeat-containing protein 27) is a protein encoded by the *LRRC27* gene located on chromosome 9q34.3. As a member of the leucine-rich repeat (LRR) superfamily, LRRC27 features conserved LRR domains, which mediate protein-protein interactions and cellular signaling. This protein is primarily expressed in tissues such as the prostate, heart, and skeletal muscle, and is implicated in regulating cytoskeletal organization, cell adhesion, and tissue morphogenesis. Studies suggest its involvement in modulating Rho GTPase signaling pathways, which govern cell motility and polarity.
LRRC27 has garnered attention due to its potential role in pathological processes, including cancer progression and cardiovascular diseases. For example, it interacts with integrin α6β4. a key player in tumor invasion, and may influence prostate cancer metastasis. Additionally, LRRC27 is linked to arterial stiffness and vascular remodeling, highlighting its relevance in cardiovascular research.
The recombinant form, produced via heterologous expression systems (e.g., E. coli or mammalian cells), serves as a critical tool for elucidating molecular mechanisms, antibody development, and high-throughput drug screening. Its structural and functional characterization remains an active area of research, with implications for therapeutic targeting in oncology and vascular diseases.
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