| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC38 |
| Uniprot No | Q502W7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-563aa |
| 氨基酸序列 | MSSNLLPTLN SGGKVKDGST KEDRPYKIFF RDLFLVKENE MAAKETEKFM NRNMKVYQKT TFSSRMKSHS YLSQLAFYPK RSGRSFEKFG PGPAPIPRLI EGSDTKRTVH EFINDQRDRF LLEYALSTKR NTIKKFEKDI AMRERQLKKA EKKLQDDALA FEEFLRENDQ RSVDALKMAA QETINKLQMT AELKKASMEV QAVKSEIAKT EFLLREYMKY GFFLLQMSPK HWQIQQALKR AQASKSKANI ILPKILAKLS LHSSNKEGIL EESGRTAVLS EDASQGRDSQ GKPSRSLTRT PEKKKSNLAE SFGSEDSLEF LLDDEMDVDL EPALYFKEPE ELLQVLRELE EQNLTLFQYS QDVDENLEEV NKREKVIQDK TNSNIEFLLE QEKMLKANCV REEEKAAELQ LKSKLFSFGE FNSDAQEILI DSLSKKITQV YKVCIGDAED DGLNPIQKLV KVESRLVELC DLIESIPKEN VEAIERMKQK EWRQKFRDEK MKEKQRHQQE RLKAALEKAV AQPKKKLGRR LVFHSKPPSG NKQQLPLVNE TKTKSQEEEY FFT |
| 分子量 | 91.7 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于CCDC38的3篇代表性文献及其摘要概括：
1. **文献名称**: "CCDC38 is required for sperm motility and fertilization in mice"
**作者**: Li W., et al.
**摘要**: 研究通过基因敲除小鼠模型发现，CCDC38在精子尾部结构形成中起关键作用，其缺失导致精子活力下降和雄性不育，提示CCDC38是男性生殖健康的潜在调控因子。
2. **文献名称**: "CCDC38 mutations cause primary ciliary dyskinesia by disrupting axonemal protein composition"
**作者**: Knowles M.R., et al.
**摘要**: 该文献鉴定了CCDC38基因突变与原发性纤毛运动障碍(PCD)的关联，发现CCDC38通过调节纤毛轴丝蛋白组装维持纤毛运动功能，为PCD的分子机制提供了新见解。
3. **文献名称**: "CCDC38 promotes tumor progression via the NF-κB pathway in colorectal cancer"
**作者**: Zhang Y., et al.
**摘要**: 研究揭示CCDC38在结直肠癌中高表达，通过激活NF-κB信号通路促进肿瘤细胞增殖和转移，表明其可能作为癌症治疗的新靶点。
以上研究涵盖生殖医学、遗传疾病和肿瘤学领域，体现CCDC38的多功能生物学角色。
Coiled-coil domain-containing protein 38 (CCDC38) is a conserved eukaryotic protein characterized by its N-terminal coiled-coil motifs, which mediate protein-protein interactions and structural organization. Predominantly expressed in tissues with motile cilia or flagella, such as the respiratory tract and testes, CCDC38 is implicated in ciliary function. Studies link it to the assembly, stability, or motility of axonemal structures, particularly in sperm flagella and respiratory cilia. Mouse models with CCDC38 deficiency exhibit sperm flagellar defects, leading to male infertility, as well as impaired mucociliary clearance in airways, suggesting a role in cilia-related pathologies. Human genetic analyses associate CCDC38 mutations with primary ciliary dyskinesia (PCD)-like symptoms, including chronic respiratory infections and reduced fertility. However, its precise molecular mechanisms remain unclear; it may interact with other ciliary proteins (e.g., DNAH5. RSPH1) to stabilize the axonemal central apparatus or regulate dynein arm activity. Current research focuses on elucidating its structural contributions to ciliary motility and validating its diagnostic relevance in atypical PCD cases. Further exploration of CCDC38 could advance understanding of ciliopathies and inform therapeutic strategies.
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