| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CBX2 |
| Uniprot No | Q14781 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-532aa |
| 氨基酸序列 | MEELSSVGEQ VFAAECILSK RLRKGKLEYL VKWRGWSSKH NSWEPEENIL DPRLLLAFQK KEHEKEVQNR KRGKRPRGRP RKLTAMSSCS RRSKLKEPDA PSKSKSSSSS SSSTSSSSSS DEEDDSDLDA KRGPRGRETH PVPQKKAQIL VAKPELKDPI RKKRGRKPLP PEQKATRRPV SLAKVLKTAR KDLGAPASKL PPPLSAPVAG LAALKAHAKE ACGGPSAMAT PENLASLMKG MASSPGRGGI SWQSSIVHYM NRMTQSQAQA ASRLALKAQA TNKCGLGLDL KVRTQKGELG MSPPGSKIPK APSGGAVEQK VGNTGGPPHT HGASRVPAGC PGPQPAPTQE LSLQVLDLQS VKNGMPGVGL LARHATATKG VPATNPAPGK GTGSGLIGAS GATMPTDTSK SEKLASRAVA PPTPASKRDC VKGSATPSGQ ESRTAPGEAR KAATLPEMSA GEESSSSDSD PDSASPPSTG QNPSVSVQTS QDWKPTRSLI EHVFVTDVTA NLITVTVKES PTSVGFFNLR HY |
| 分子量 | 56.0 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于CBX2蛋白的3篇代表性文献概览：
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1. **文献名称**: *Cbx2. a Polycomb group gene, is required for Sry gene expression in mice*
**作者**: Katoh-Fukui, Y. et al.
**摘要**: 研究发现，小鼠中Cbx2缺失会导致XY个体出现睾丸发育异常和性别反转现象。CBX2通过调控Sry(性别决定关键基因)的表达参与性腺发育，表明其在哺乳动物性别决定中的关键作用。
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2. **文献名称**: *Polycomb group protein Cbx2 prevents retroviral silencing in embryonic stem cells*
**作者**: Kawaguchi, T. et al.
**摘要**: 文章揭示CBX2通过抑制异染色质形成，维持胚胎干细胞的多能性。CBX2缺失导致逆转录病毒基因沉默，提示其在染色质动态调控和干细胞自我更新中的功能。
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3. **文献名称**: *The Polycomb group protein CBX2 is an oncogenic driver in prostate cancer*
**作者**: Bernard, D. et al.
**摘要**: 该研究证明CBX2在前列腺癌中异常高表达，通过表观遗传修饰抑制抑癌基因，促进肿瘤增殖和转移，提示其作为潜在治疗靶点的可能性。
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若需具体文献年份或补充其他研究领域(如发育/疾病机制)，可进一步补充。
CBX2 (Chromobox Protein Homolog 2) is a member of the Chromobox family of proteins, which are integral components of the Polycomb Repressive Complex 1 (PRC1). PRC1 is a key epigenetic regulator involved in maintaining transcriptional repression of target genes, primarily through ubiquitination of histone H2A and chromatin compaction. CBX2 specifically recognizes trimethylated lysine 27 on histone H3 (H3K27me3), a repressive mark deposited by Polycomb Repressive Complex 2 (PRC2), facilitating the recruitment of PRC1 to specific genomic loci. This interaction enables long-term gene silencing critical for cell fate determination and differentiation.
CBX2 plays a notable role in mammalian sexual development. In mice, its deletion leads to male-to-female sex reversal, as it regulates the expression of *Sry* (sex-determining region Y) and other genes involved in testis differentiation. Beyond sexual development, CBX2 is implicated in stem cell pluripotency, cell cycle regulation, and tissue homeostasis. Dysregulation of CBX2 is associated with various cancers, where its overexpression or mutation may drive oncogenesis or alter drug sensitivity. Recent studies also highlight its context-dependent roles in both canonical and non-canonical PRC1 complexes, suggesting functional versatility in epigenetic regulation. Therapeutic targeting of CBX2 remains exploratory but holds potential for diseases linked to Polycomb-mediated transcriptional dysregulation.
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