首页 / 产品 / 蛋白 / 细胞因子、趋化因子与生长因子
| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | GCP2 |
| Uniprot No | Q04609 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 48-750aa |
| 氨基酸序列 | EATNITPKHNMKAFLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYPNKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYARTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVKSYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYYDAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFASWDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKELKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDYAVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIVLRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVDPSKAWGEVKRQIYVAAFTVQAAAETLSEVA |
| 预测分子量 | 83.1kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于GCP2重组蛋白的示例参考文献(注：以下内容为模拟生成，实际文献可能存在差异)：
1. **文献名称**: "Expression and functional characterization of recombinant human GCP2 in Escherichia coli"
**作者**: Smith A, et al.
**摘要**: 研究报道了在大肠杆菌中高效表达人源GCP2重组蛋白的优化方法，通过His标签纯化获得高纯度蛋白，并验证其促进特定免疫细胞迁移的趋化活性。
2. **文献名称**: "Structural analysis of GCP2 reveals its role in microtubule dynamics during mitosis"
**作者**: Chen L, et al.
**摘要**: 通过X射线晶体学解析GCP2重组蛋白的三维结构，揭示其与微管结合的关键结构域，证实其在细胞分裂过程中调控微管组装的分子机制。
3. **文献名称**: "GCP2 recombinant protein enhances neuronal regeneration in vitro"
**作者**: Wang Y, et al.
**摘要**: 在哺乳动物细胞中表达GCP2重组蛋白，发现其通过激活PI3K/AKT信号通路促进神经元轴突再生，为神经损伤修复研究提供实验依据。
4. **文献名称**: "Development of a GCP2-based biosensor for drug screening"
**作者**: Kim T, et al.
**摘要**: 利用重组GCP2蛋白构建荧光标记生物传感器，成功应用于高通量筛选调控细胞周期进程的小分子化合物，具有潜在药物开发价值。
(注：以上文献信息为虚构示例，实际研究中请通过学术数据库检索具体文献。)
**Background of GCP2 Recombinant Protein**
GCP2 (Granzyme-Caspase Pathway Protein 2) is a synthetic or engineered protein derived from recombinant DNA technology, designed to mimic or enhance the functional properties of its native counterpart. Native GCP2 is implicated in critical cellular processes, particularly apoptosis and immune regulation, through its interaction with granzymes and caspases—key enzymes in programmed cell death and inflammation. Its recombinant form is often generated using expression systems like *E. coli*, yeast, or mammalian cell lines, enabling scalable production with high purity and consistency for research and therapeutic applications.
The recombinant GCP2 protein typically retains functional domains essential for binding proteases or signaling molecules, allowing it to serve as a tool for studying apoptosis pathways, immune cell cytotoxicity, or pathogen-host interactions. Its structure may include tags (e.g., His-tag) for simplified purification and detection. In drug development, GCP2 recombinant protein is explored for modulating immune responses, such as enhancing T-cell-mediated tumor clearance or mitigating autoimmune disorders. Additionally, it aids in structural studies (e.g., X-ray crystallography) to map interaction sites for targeted therapy design.
Research applications also extend to biomarker discovery, where GCP2’s role in disease progression—such as cancer or neurodegenerative conditions—is investigated. By leveraging recombinant GCP2. scientists gain insights into its mechanistic contributions to cell death regulation, offering potential avenues for novel diagnostics or therapeutics. Overall, GCP2 recombinant protein bridges fundamental biology and translational medicine, underscoring its versatility in both academic and industrial settings.
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