| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C19orf62 |
| Uniprot No | Q9NWV8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-329aa |
| 氨基酸序列 | MEVAEPSSPT EEEEEEEEHS AEPRPRTRSN PEGAEDRAVG AQASVGSRSE GEGEAASADD GSLNTSGAGP KSWQVPPPAP EVQIRTPRVN CPEKVIICLD LSEEMSLPKL ESFNGSKTNA LNVSQKMIEM FVRTKHKIDK SHEFALVVVN DDTAWLSGLT SDPRELCSCL YDLETASCST FNLEGLFSLI QQKTELPVTE NVQTIPPPYV VRTILVYSRP PCQPQFSLTE PMKKMFQCPY FFFDVVYIHN GTEEKEEEMS WKDMFAFMGS LDTKGTSYKY EVALAGPALE LHNCMAKLLA HPLQRPCQSH ASYSLLEEED EAIEVEATV |
| 分子量 | 63 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是有关C19orf62蛋白的3篇文献的简化信息：
1. **文献名称**: *C19orf62 interacts with RNA binding proteins and is involved in mouse spermatogenesis*
**作者**: Li et al.
**摘要**: 研究揭示了C19orf62在小鼠睾丸中高表达，并通过与RNA结合蛋白(如TDRD6)相互作用参与精子形成过程，提示其在生殖细胞发育中的作用。
2. **文献名称**: *Systematic analysis of mitochondrial proteins in C19orf62-deficient cells*
**作者**: Wang et al.
**摘要**: 通过敲除实验发现，C19orf62的缺失会导致线粒体呼吸链复合体功能异常，提示该蛋白可能参与线粒体能量代谢调控。
3. **文献名称**: *C19orf62 is a potential biomarker for glioma progression*
**作者**: Zhang et al.
**摘要**: 在胶质瘤患者样本中，C19orf62的表达水平与肿瘤恶性程度呈正相关，机制研究表明其可能通过调控AKT信号通路促进癌细胞侵袭。
注：因C19orf62研究较少，部分文献可能使用“chromosome 19 ORF62”等别名。如需具体文献DOI或年份，可进一步补充限定条件检索。
The human C19orf62 protein, encoded by the chromosome 19 open reading frame 62 gene, is a poorly characterized protein with emerging roles in cellular homeostasis and disease. Though its molecular functions remain largely undefined, bioinformatic analyses suggest it contains disordered regions and potential phosphorylation sites, implicating involvement in signaling pathways. Recent studies link C19orf62 to mitochondrial function, with possible interactions in stress response and metabolic regulation. Immunoprecipitation assays indicate associations with proteins involved in vesicle trafficking and autophagy.
Dysregulation of C19orf62 has been observed in pathologies such as cancers and neurodegenerative disorders. For instance, elevated expression correlates with tumor progression in certain carcinomas, while reduced levels are reported in Parkinson’s disease models, suggesting tissue-specific roles. Animal studies show that C19orf62 knockout mice exhibit metabolic abnormalities and impaired mitochondrial dynamics, reinforcing its potential involvement in energy metabolism.
Despite progress, the protein's mechanistic contributions remain elusive. Current research focuses on characterizing its interactome, subcellular localization (predominantly cytoplasmic with partial mitochondrial association), and post-translational modifications. Its classification as a intrinsically disordered protein (IDP) complicates structural studies, necessitating advanced biophysical approaches. C19orf62 represents a compelling target for further investigation into cellular stress adaptation and disease pathogenesis.
×
