| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C19orf61 |
| Uniprot No | Q9H0W8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-520aa |
| 氨基酸序列 | MSESGHSQPGLYGIERRRRWKEPGSGGPQNLSGPGGRERDYIAPWERERRDASEETSTSVMQKTPIILSKPPAERSKQPPPPTAPAAPPAPAPLEKPIVLMKPREEGKGPVAVTGASTPEGTAPPPPAAPAPPKGEKEGQRPTQPVYQIQNRGMGTAAPAAMDPVVGQAKLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKSMVMSLLSANTPEEDQRTYVFRAQSAEMKERGGNQTSGIDFFITQERIVFLDTQPILSPSILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFTDLSLYRFLQTAEMVKPSTPSPSHESSSSSGSDEGTEYYPHLVFLQNKARREDFCPRKLRQMHLMIDQLMAHSHLRYKGTLSMLQCNVFPGLPPDFLDSEVNLFLVPFMDSEAESENPPRAGPGSSPLFSLLPGYRGHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVRKSSALAEYSRLLA |
| 分子量 | 84.1 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C19orf61蛋白的模拟参考文献示例(文献内容为综合概括，实际研究需通过学术数据库验证)：
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1. **文献名称**: *C19orf61 Encodes a Mitochondrial Protein Regulating Cell Proliferation*
**作者**: Zhang L et al. (2022)
**摘要**: 研究发现C19orf61蛋白定位于线粒体，通过调控ROS水平影响细胞周期进程。重组蛋白实验表明其过表达可抑制肿瘤细胞增殖，提示潜在抑癌功能。
2. **文献名称**: *Structural Characterization of Human C19orf61 and Its Role in Lipid Metabolism*
**作者**: Kim S et al. (2020)
**摘要**: 解析了重组人C19orf61蛋白的晶体结构，证实其与脂肪酸结合蛋白家族的结构相似性。体外实验显示其参与肝细胞脂质代谢调控，可能与代谢综合征相关。
3. **文献名称**: *C19orf61 as a Novel Biomarker in Alzheimer's Disease*
**作者**: Wang Y et al. (2021)
**摘要**: 通过蛋白质组学筛选发现，C19orf61在阿尔茨海默患者脑脊液中表达异常。重组蛋白模型证实其与Aβ肽相互作用，可能影响淀粉样斑块沉积。
4. **文献名称**: *Optimizing Recombinant Expression of C19orf61 in E. coli for Functional Studies*
**作者**: Patel R et al. (2019)
**摘要**: 报道了C19orf61蛋白在大肠杆菌中的重组表达与纯化策略，优化可溶性表达条件，并验证其体外磷酸化活性，为后续功能研究提供方法学基础。
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**注意**：以上文献为示例性质，具体研究需以实际数据库(如PubMed、Web of Science)检索结果为准。建议结合基因别名(如HGNC命名)扩展检索范围。
**Background of Recombinant Human C19orf61 Protein**
The C19orf61 gene, located on chromosome 19. encodes a protein also referred to as FAM210A or YJEFN3. Although its functional characterization remains limited, emerging studies suggest its involvement in mitochondrial metabolism and cellular homeostasis. The protein is evolutionarily conserved, indicating potential roles in fundamental biological processes. Structurally, it contains a putative mitochondrial-targeting signal, implying localization to mitochondria, where it may interact with mitochondrial ribosomes or regulate protein synthesis.
C19orf61 has been linked to skeletal muscle function and metabolic regulation. Knockdown models in mice show muscle atrophy and impaired mitochondrial respiration, suggesting its importance in maintaining muscle integrity and energy balance. Additionally, dysregulation of C19orf61 expression correlates with diseases such as sarcopenia, cancer, and metabolic syndromes, highlighting its potential as a therapeutic or diagnostic target.
Recombinant C19orf61 protein is typically produced using bacterial or mammalian expression systems, often fused with tags (e.g., His-tag) for purification. It serves as a tool for antibody development, protein interaction studies, and mechanistic investigations into mitochondrial dysfunction. Ongoing research aims to elucidate its precise molecular mechanisms and explore its relevance in aging and disease pathology. Further studies are needed to validate its interactome and therapeutic potential.
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