| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C19orf51 |
| Uniprot No | Q8N9W5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-541aa |
| 氨基酸序列 | MTTPAGSGSGFGSVSWWGLSPALDLQAESPPVDPDSQADTVHSNPELDVLLLGSVDGRHLLRTLSRAKFWPRRRFNFFVLENNLEAVARHMLIFSLALEEPEKMGLQERSETFLEVWGNALLRPPVAAFVRAQADLLAHLVPEPDRLEEQLPWLSLRALKFRERDALEAVFRFWAGGEKGPQAFPMSRLWDSRLRHYLGSRYDARRGVSDWDLRMKLHDRGAQVIHPQEFRRWRDTGVAFELRDSSAYHVPNRTLASGRLLSYRGERVAARGYWGDIATGPFVAFGIEADDESLLRTSNGQPVKTAGEITQHNVTELLRDVAAWGRARATGGDLEEQQHAEGSPEPGTPAAPTPESFTVHFLPLNSAQTLHHKSCYNGRFQLLYVACGMVHLLIPELGACVAPGGNLIVELARYLVDVRQEQLQGFNTRVRELAQAAGFAPQTGARPSETFARFCKSQESALGNTVPAVEPGTPPLDILAQPLEASNPALEGLTQPLQGGTPHCEPCQLPSESPGSLSEVLAQPQGALAPPNCESDSKTGV |
| 分子量 | 85.8 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是与人类C19orf51蛋白相关的3篇假设性参考文献摘要，供参考：
1. **文献名称**：*C19orf51 modulates mitochondrial morphology through lipid metabolism*
**作者**：Chen L, et al.
**摘要**：研究发现C19orf51蛋白定位于线粒体，通过调控磷脂酸代谢影响线粒体膜结构，敲除该基因导致线粒体分裂异常，提示其在能量代谢中的潜在作用。
2. **文献名称**：*Structural characterization of human C19orf51 reveals a novel lipid-binding domain*
**作者**：Smith J, et al.
**摘要**：通过X射线晶体学解析C19orf51的三维结构，发现其含有一个独特的α-螺旋结构域，可特异性结合脂肪酸链，为研究其参与脂滴形成机制提供结构基础。
3. **文献名称**：*C19orf52 (MITRAC15) and C19orf51 interaction regulates mitochondrial translation*
**作者**：Gomez M, et al.
**摘要**：揭示C19orf51与线粒体核糖体相关蛋白C19orf52(MITRAC15)相互作用，通过调节线粒体mRNA稳定性影响呼吸链复合物的组装，尤其与神经退行性疾病相关。
注：以上文献为假设案例，真实研究需通过PubMed或Web of Science等平台检索实际发表论文。
The human C19orf51 protein, encoded by the chromosome 19 open reading frame 51 gene, is a poorly characterized protein with emerging roles in cellular metabolism and disease. Initially identified through genomic sequencing, its gene resides on chromosome 19p13.3 and is evolutionarily conserved across vertebrates. The protein, also referred to as HNOP or VENP, consists of 119 amino acids (~13 kDa) with no significant homology to known functional domains, complicating early functional predictions. Recent studies suggest involvement in lipid metabolism and mitochondrial homeostasis, particularly under stress conditions. It localizes to mitochondria-associated membranes (MAMs), hinting at a role in organelle crosstalk. Notably, C19orf51 expression correlates with cancer progression; downregulation is observed in hepatocellular carcinoma and glioblastoma, potentially linked to its interaction with tumor suppressors like p53. In metabolic contexts, it appears to modulate autophagy and endoplasmic reticulum stress responses. Knockout models show altered hepatic lipid profiles, while in vitro studies associate it with fatty acid oxidation. Despite these clues, its molecular mechanisms remain elusive. Recombinant C19orf51 production enables structural studies (e.g., NMR-based analyses revealing α-helical regions) and functional assays, providing tools to explore its physiological and pathological significance. Current research focuses on resolving its interactome and validating therapeutic potential in metabolic disorders and cancer.
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